Mouse Anti-DDX60 Recombinant Antibody (1A10) (V2LY-0425-LY125)

Name: Mouse Anti-DDX60 Recombinant Antibody (1A10)
SKU: V2LY-0425-LY125
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

1A10

Antibody Isotype

IgG1, κ

Application

ELISA, WB

Basic Information

Immunogen

DDX60 full length recombinant protein.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal Antibody

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

Batch dependent

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

DEAD (Asp-Glu-Ala-Asp) box polypeptide 60

Entrez Gene ID

55601

UniProt ID

Q8IY21

Function

Positively regulates DDX58/RIG-I- and IFIH1/MDA5-dependent type I interferon and interferon inducible gene expression in response to viral infection. Binds ssRNA, dsRNA and dsDNA and can promote the binding of DDX58/RIG-I to dsRNA. Exhibits antiviral activity against hepatitis C virus and vesicular stomatitis virus (VSV).

Biological Process

Defense response to virus Source: UniProtKB-KW
Innate immune response Source: UniProtKB-KW
Positive regulation of MDA-5 signaling pathway Source: UniProtKB
Positive regulation of RIG-I signaling pathway Source: UniProtKB
Response to virus Source: UniProtKB

Cellular Location

Cytoplasm

More Infomation

References

Sadic, M., Schneider, W. M., Katsara, O., Medina, G. N., Mogulothu, A., Yu, Y., ... & Dittmann, M. (2022). Antiviral DExD/H-box helicase 60 selectively inhibits translation from type II internal ribosome entry sites. bioRxiv.

Karasawa, T., Sato, R., Imaizumi, T., Hashimoto, S., Fujita, M., Aizawa, T., ... & Tanaka, H. (2022). Glomerular endothelial expression of type I IFN-stimulated gene, DExD/H-Box helicase 60 via toll-like receptor 3 signaling: possible involvement in the pathogenesis of lupus nephritis. Renal Failure, 44(1), 137-145.

Xin, D., Liu, J., Gu, J., Ji, Y., Jin, J., Sun, L., ... & Tang, Z. (2020). Low expression of DDX60 gene might associate with the radiosensitivity for patients with breast cancer. Journal of oncology, 2020.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Alternative Versions

Mouse Anti-DDX60 Recombinant Antibody (1A10)

Related Products

Mouse Anti-DDX60 Recombinant Antibody (1A10)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Datasheet
SDS
Request for COA

Request bulk or custom quote Online Inquiry
Second antibody and isotype control

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