Mouse Anti-DEFA6 Recombinant Antibody (2D2) (CBMAB-D0680-YC)

Name: Mouse Anti-DEFA6 Recombinant Antibody (2D2)
SKU: CBMAB-D0680-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

2D2

Application

ELISA, WB

Immunogen

DEFA6 (NP_001917.1, 1 a.a. ~ 100 a.a) full-length recombinant protein with GST tag. The immunogen sequence: MRTLTILTAV LLVALQAKAE PLQAEDDPLQ AKAYEADAQE QRGANDQDFA VSFAEDASSS LRALGSTRAF TCHCRRSCYS TEYSYGTCTV MGINHRFCCL

Specificity

Human

Antibody Isotype

IgG2a, κ

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 1-100

More Infomation

Target

Full Name

defensin, alpha 6, Paneth cell-specific

Introduction

Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. DEFA6 is highly expressed in the secretory granules of Paneth cells of the small intestine, and likely plays a role in host defense of human bowel.

Entrez Gene ID

1671

UniProt ID

Q01524

Alternative Names

Defensin Alpha 6; Defensin, Alpha 6, Paneth Cell-Specific; DEF6; Defensin, Alpha 6; Defensin-6; HD-6;

Function

Has very low antimicrobial activity against Gram-negative and Gram-positive bacteria. May protect cells against infection with HIV-1.

Biological Process

Antibacterial humoral response Source: GO_Central
Antimicrobial humoral immune response mediated by antimicrobial peptide Source: GO_Central
Antimicrobial humoral response Source: Reactome
Cellular response to lipopolysaccharide Source: GO_Central
Defense response to fungus Source: UniProtKB-KW
Defense response to Gram-negative bacterium Source: GO_Central
Defense response to Gram-positive bacterium Source: GO_Central
Innate immune response in mucosa Source: GO_Central
Killing of cells of other organism Source: UniProtKB
Membrane disruption in other organism Source: GO_Central

Cellular Location

Secreted

Wei, P. L., Lin, J. C., Hung, C. S., Makondi, P. T., Batzorig, U., Chang, T. C., ... & Chang, Y. J. (2022). Human α-defensin 6 (HD6) suppresses CRC proliferation and metastasis through abolished EGF/EGFR signaling pathway. International journal of medical sciences, 19(1), 34.

Jeong, D., Kim, H., Kim, D., Ban, S., Oh, S., Ji, S., ... & Baek, M. J. (2019). Defensin alpha 6 (DEFA6) is a prognostic marker in colorectal cancer. Cancer Biomarkers, 24(4), 485-495.

Markasz, L., Wanders, A., Szekely, L., & Lilja, H. E. (2018). Diminished DEFA6 expression in paneth cells is associated with necrotizing enterocolitis. Gastroenterology Research and Practice, 2018.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Alternative Versions

Mouse Anti-DEFA6 Recombinant Antibody (2D2) (CAT#: V2LY-0425-LY158)

Related Products

Mouse Anti-DEFA6 Recombinant Antibody (2D2) (CAT#: V2LY-0425-LY158)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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