Sign in or Register   Sign in or Register
  |  

Mouse Anti-DEFA6 Recombinant Antibody (2D2) (CBMAB-D0680-YC)

Provided herein is a Mouse monoclonal antibody, which binds to Defensin Alpha 6 (DEFA6). The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all DEFA6 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2D2
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
DEFA6 (NP_001917.1, 1 a.a. ~ 100 a.a) full-length recombinant protein with GST tag. The immunogen sequence: MRTLTILTAV LLVALQAKAE PLQAEDDPLQ AKAYEADAQE QRGANDQDFA VSFAEDASSS LRALGSTRAF TCHCRRSCYS TEYSYGTCTV MGINHRFCCL
Specificity
Human
Antibody Isotype
IgG2a, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-100

Target

Full Name
defensin, alpha 6, Paneth cell-specific
Introduction
Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. DEFA6 is highly expressed in the secretory granules of Paneth cells of the small intestine, and likely plays a role in host defense of human bowel.
Entrez Gene ID
1671
UniProt ID
Q01524
Alternative Names
Defensin Alpha 6; Defensin, Alpha 6, Paneth Cell-Specific; DEF6; Defensin, Alpha 6; Defensin-6; HD-6;
Function
Has very low antimicrobial activity against Gram-negative and Gram-positive bacteria. May protect cells against infection with HIV-1.
Biological Process
Antibacterial humoral response Source: GO_Central
Antimicrobial humoral immune response mediated by antimicrobial peptide Source: GO_Central
Antimicrobial humoral response Source: Reactome
Cellular response to lipopolysaccharide Source: GO_Central
Defense response to fungus Source: UniProtKB-KW
Defense response to Gram-negative bacterium Source: GO_Central
Defense response to Gram-positive bacterium Source: GO_Central
Innate immune response in mucosa Source: GO_Central
Killing of cells of other organism Source: UniProtKB
Membrane disruption in other organism Source: GO_Central
Cellular Location
Secreted
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-DEFA6 Recombinant Antibody (2D2)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare