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Mouse Anti-DHRS2 Recombinant Antibody (1F10) (CBMAB-D0842-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
1F10
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
DHRS2 (NP_878912.1, 229 a.a. ~ 300 a.a) partial recombinant protein with GST tag. The immunogen sequence: GFMGMSLSGR TSRNIISCRG LGSQRTVQES CPSCALQMPA TSTGRTLRWQ ATPLGSERSG GGCVAVVPGP GA
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 229-300

Target

Full Name
Dehydrogenase/Reductase 2
Introduction
DHRS2 belongs to the short-chain dehydrogenases/reductases (SDR) family, which has over 46,000 members. Members of this family are enzymes that metabolize many different compounds, such as steroid hormones, prostaglandins, retinoids, lipids and xenobiotics. Alternative promoter use and alternative splicing results in multiple transcript variants.
Entrez Gene ID
10202
UniProt ID
Q13268
Alternative Names
Dehydrogenase/Reductase 2; Short Chain Dehydrogenase/Reductase Family 25C Member 1; Dehydrogenase/Reductase (SDR Family) Member 2; Dicarbonyl Reductase HEP27; Protein D; SDR25C1; Dehydrogenase/Reductase SDR Family Member 2, Mitochondrial;
Function
Displays NADPH-dependent dicarbonyl reductase activity in vitro with 3,4-Hexanedione, 2,3-Heptanedione and 1-Phenyl-1,2-propanedione as substrates. No reductase activity is displayed in vitro with steroids, retinoids and sugars as substrates. Attenuates MDM2-mediated p53/TP53 degradation, leading to p53/TP53 stabilization and increased transcription activity, resulting in the accumulation of MDM2 and CDKN1A/p21.
Biological Process
C21-steroid hormone metabolic process Source: UniProtKB
Cellular response to oxidative stress Source: UniProtKB
Electron transport chain Source: UniProtKB
Myeloid dendritic cell differentiation Source: UniProtKB
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of cell population proliferation Source: UniProtKB
Response to toxic substance Source: UniProtKB
Cellular Location
Mitochondrion matrix; Nucleus. A minor fraction of the protein is translocated from the mitochondria to the nucleus, after cleavage of the targeting signal.
More Infomation

Li, Z., Liu, H., Bode, A., & Luo, X. (2021). Emerging roles of dehydrogenase/reductase member 2 (DHRS2) in the pathology of disease. European Journal of Pharmacology, 898, 173972.

Yaylaz, B. S., Ekmekci, S. S., Çınar, S., Deniz, G., & Abacı, N. (2021). DHRS2 is a potential marker of breast cancer metastasis. Gene Reports, 25, 101302.

Yamashita, T. (2020). HSF1 Regulates Cellular Senescence: Role of the DHRS2-MDM2-p53 Pathway. In Heat Shock Proteins in Human Diseases (pp. 237-248). Springer, Cham.

Nettersheim, D., Berger, D., Jostes, S., Skowron, M., & Schorle, H. (2019). Deciphering the molecular effects of romidepsin on germ cell tumours: DHRS 2 is involved in cell cycle arrest but not apoptosis or induction of romidepsin effectors. Journal of Cellular and Molecular Medicine, 23(1), 670-679.

Li, J. M., Jiang, G. M., Zhao, L., Yang, F., Yuan, W. Q., Wang, H., & Luo, Y. Q. (2019). Dehydrogenase/reductase SDR family member 2 silencing sensitizes an oxaliplatin‑resistant cell line to oxaliplatin by inhibiting excision repair cross‑complementing group 1 protein expression. Oncology Reports, 42(5), 1725-1734.

Luo, X., Li, N., Zhao, X., Liao, C., Ye, R., Cheng, C., ... & Cao, Y. (2019). DHRS2 mediates cell growth inhibition induced by Trichothecin in nasopharyngeal carcinoma. Journal of Experimental & Clinical Cancer Research, 38(1), 1-14.

Zhou, Y., Wang, L., Ban, X., Zeng, T., Zhu, Y., Li, M., ... & Li, Y. (2018). DHRS2 inhibits cell growth and motility in esophageal squamous cell carcinoma. Oncogene, 37(8), 1086-1094.

Han, Y., Song, C., Wang, J., Tang, H., Peng, Z., & Lu, S. (2018). HOXA13 contributes to gastric carcinogenesis through DHRS2 interacting with MDM2 and confers 5‐FU resistance by a p53‐dependent pathway. Molecular carcinogenesis, 57(6), 722-734.

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For research use only. Not intended for any clinical use.

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