Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

Mouse Anti-DHRS2 Recombinant Antibody (1F10) (V2LY-0425-LY283)


See all DHRS2 antibodies
Online Inquiry

Summary

Host Animal
Mouse
Specificity
Human
Clone
1F10
Antibody Isotype
IgG2a, κ
Application
ELISA, WB, IP

Basic Information

Immunogen
Amino acids 229-300 representing partial length of human DHRS2.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
ELISA1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Gelatin & PBS
Preservative
Sodium Azide
Concentration
0.1 mg/ml
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Dehydrogenase/Reductase 2
Entrez Gene ID
10202
UniProt ID
Q13268
Function
Displays NADPH-dependent dicarbonyl reductase activity in vitro with 3,4-Hexanedione, 2,3-Heptanedione and 1-Phenyl-1,2-propanedione as substrates. No reductase activity is displayed in vitro with steroids, retinoids and sugars as substrates. Attenuates MDM2-mediated p53/TP53 degradation, leading to p53/TP53 stabilization and increased transcription activity, resulting in the accumulation of MDM2 and CDKN1A/p21.
Biological Process
C21-steroid hormone metabolic process Source: UniProtKB
Cellular response to oxidative stress Source: UniProtKB
Electron transport chain Source: UniProtKB
Myeloid dendritic cell differentiation Source: UniProtKB
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of cell population proliferation Source: UniProtKB
Response to toxic substance Source: UniProtKB
Cellular Location
Mitochondrion matrix; Nucleus. A minor fraction of the protein is translocated from the mitochondria to the nucleus, after cleavage of the targeting signal.
More Infomation

Li, Z., Liu, H., Bode, A., & Luo, X. (2021). Emerging roles of dehydrogenase/reductase member 2 (DHRS2) in the pathology of disease. European Journal of Pharmacology, 898, 173972.

Yaylaz, B. S., Ekmekci, S. S., Çınar, S., Deniz, G., & Abacı, N. (2021). DHRS2 is a potential marker of breast cancer metastasis. Gene Reports, 25, 101302.

Yamashita, T. (2020). HSF1 Regulates Cellular Senescence: Role of the DHRS2-MDM2-p53 Pathway. In Heat Shock Proteins in Human Diseases (pp. 237-248). Springer, Cham.

Nettersheim, D., Berger, D., Jostes, S., Skowron, M., & Schorle, H. (2019). Deciphering the molecular effects of romidepsin on germ cell tumours: DHRS 2 is involved in cell cycle arrest but not apoptosis or induction of romidepsin effectors. Journal of Cellular and Molecular Medicine, 23(1), 670-679.

Li, J. M., Jiang, G. M., Zhao, L., Yang, F., Yuan, W. Q., Wang, H., & Luo, Y. Q. (2019). Dehydrogenase/reductase SDR family member 2 silencing sensitizes an oxaliplatin‑resistant cell line to oxaliplatin by inhibiting excision repair cross‑complementing group 1 protein expression. Oncology Reports, 42(5), 1725-1734.

Luo, X., Li, N., Zhao, X., Liao, C., Ye, R., Cheng, C., ... & Cao, Y. (2019). DHRS2 mediates cell growth inhibition induced by Trichothecin in nasopharyngeal carcinoma. Journal of Experimental & Clinical Cancer Research, 38(1), 1-14.

Zhou, Y., Wang, L., Ban, X., Zeng, T., Zhu, Y., Li, M., ... & Li, Y. (2018). DHRS2 inhibits cell growth and motility in esophageal squamous cell carcinoma. Oncogene, 37(8), 1086-1094.

Han, Y., Song, C., Wang, J., Tang, H., Peng, Z., & Lu, S. (2018). HOXA13 contributes to gastric carcinogenesis through DHRS2 interacting with MDM2 and confers 5‐FU resistance by a p53‐dependent pathway. Molecular carcinogenesis, 57(6), 722-734.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-DHRS2 Recombinant Antibody (1F10)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Request bulk or custom quote Online Inquiry
Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Online Inquiry