Mouse Anti-DHRS9 Recombinant Antibody (CBYCD-266) (CBMAB-D0845-YC)

Name: Mouse Anti-DHRS9 Recombinant Antibody (CBYCD-266)
SKU: CBMAB-D0845-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYCD-266

Application

ELISA, ICC, IF, WB

Specificity

Human

Antibody Isotype

IgG2a, κ

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Dehydrogenase/Reductase 9

Introduction

DHRS9 belongs to the short-chain dehydrogenases/reductases (SDR) family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. This protein demonstrates oxidoreductase activity toward hydroxysteroids and is able to convert 3-alpha-tetrahydroprogesterone to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone in the cytoplasm, and may additionally function as a transcriptional repressor in the nucleus.

Entrez Gene ID

10170

UniProt ID

Q9BPW9

Alternative Names

Dehydrogenase/Reductase 9; NADP-Dependent Retinol Dehydrogenase/Reductase; 3-Alpha Hydroxysteroid Dehydrogenase; Tracheobronchial Epithelial Cell-Specific Retinol Dehydrogenase; Short Chain Dehydrogenase/Reductase Family 9C Member 4; Dehydrogenase/Reductase (SDR Family) Member 9; Short-Chain Dehydrogenase/Reductase RetSDR8; Retinol Dehydrogenase Homolog; Retinol Dehydrogenase 15; 3-Alpha-HSD; RDH-TBE; RDH-E2;

Function

3-alpha-hydroxysteroid dehydrogenase that converts 3-alpha-tetrahydroprogesterone (allopregnanolone) to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone (PubMed:11294878, PubMed:29541409).

Plays also a role in the biosynthesis of retinoic acid from retinaldehyde (PubMed:11304534, PubMed:12618084).

Can utilize both NADH and NADPH.

Biological Process

9-cis-retinoic acid biosynthetic process Source: UniProtKB
Androgen metabolic process Source: UniProtKB
Epithelial cell differentiation Source: UniProtKB
Progesterone metabolic process Source: UniProtKB
Retinol metabolic process Source: UniProtKB

Cellular Location

Microsome membrane; Endoplasmic reticulum membrane. Associated with microsomal membranes.

Belyaeva, O. V., Wirth, S. E., Boeglin, W. E., Karki, S., Goggans, K. R., Wendell, S. G., ... & Kedishvili, N. Y. (2022). Dehydrogenase reductase 9 (SDR9C4) and related homologs recognize a broad spectrum of lipid mediator oxylipins as substrates. Journal of Biological Chemistry, 298(1).

Li, H. B., Zhou, J., Zhao, F., Yu, J., & Xu, L. (2020). Prognostic impact of DHRS9 overexpression in pancreatic cancer. Cancer Management and Research, 12, 5997.

Shimomura, H., Sasahira, T., Nakashima, C., Shimomura-Kurihara, M., & Kirita, T. (2018). Downregulation of DHRS9 is associated with poor prognosis in oral squamous cell carcinoma. Pathology, 50(6), 642-647.

Bitterer, F., Amodio, G., Macedo, C., Moreau, A., Obermajer, N., Fraendrich, F., ... & Riquelme, P. (2018). DHRS9 is a Stable Marker of Human Regulatory Macrophages. Transplantation, 102, S18-S19.

Riquelme, P., Amodio, G., Macedo, C., Moreau, A., Obermajer, N., Brochhausen, C., ... & Hutchinson, J. A. (2017). DHRS9 is a stable marker of human regulatory macrophages. Transplantation, 101(11), 2731.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Mouse Anti-DHRS9 Recombinant Antibody (CBYCD-266) (CAT#: V2LY-0425-LY284)

Antibody Pairs

DHRS9 Matched Antibody Pair (340) (CAT#: APMAB-340LY)

Related Products

Mouse Anti-DHRS9 Recombinant Antibody (3C6) (CAT#: CBMAB-A2217-LY)

Mouse Anti-DHRS9 Recombinant Antibody (3C6) (CAT#: V2LY-0425-LY285)

DHRS9 Matched Antibody Pair (340) (CAT#: APMAB-340LY)

Mouse Anti-DHRS9 Recombinant Antibody (CBYCD-266) (CAT#: V2LY-0425-LY284)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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