DHRS9

This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. This protein demonstrates oxidoreductase activity toward hydroxysteroids and is able to convert 3-alpha-tetrahydroprogesterone to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone in the cytoplasm, and may additionally function as a transcriptional repressor in the nucleus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Full Name
Dehydrogenase/Reductase 9
Function
3-alpha-hydroxysteroid dehydrogenase that converts 3-alpha-tetrahydroprogesterone (allopregnanolone) to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone (PubMed:11294878, PubMed:29541409).

Plays also a role in the biosynthesis of retinoic acid from retinaldehyde (PubMed:11304534, PubMed:12618084).

Can utilize both NADH and NADPH.
Biological Process
9-cis-retinoic acid biosynthetic process Source: UniProtKB
Androgen metabolic process Source: UniProtKB
Epithelial cell differentiation Source: UniProtKB
Progesterone metabolic process Source: UniProtKB
Retinol metabolic process Source: UniProtKB
Cellular Location
Microsome membrane; Endoplasmic reticulum membrane. Associated with microsomal membranes.
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Anti-DHRS9 antibodies

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Mouse Anti-DHRS9 Recombinant Antibody (3C6) (CBMAB-A2217-LY)

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Target: DHRS9
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3C6
Application*: WB, E
Datasheet SDS

Mouse Anti-DHRS9 Recombinant Antibody (3C6) (V2LY-0425-LY285)

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Target: DHRS9
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3C6
Application*: WB, E, IF
Datasheet SDS

Mouse Anti-DHRS9 Recombinant Antibody (CBYCD-266) (V2LY-0425-LY284)

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Target: DHRS9
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYCD-266
Application*: E, WB, IP
Datasheet SDS

DHRS9 Matched Antibody Pair (340) (APMAB-340LY)

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Target: DHRS9
Specificity: Human
Datasheet SDS

Mouse Anti-DHRS9 Recombinant Antibody (CBYCD-266) (CBMAB-D0845-YC)

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Target: DHRS9
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYCD-266
Application*: E, IC, IF, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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