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Mouse Anti-DHX16 Recombinant Antibody (2268C5_2a) (CBMAB-D0847-YC)

Provided herein is a Mouse monoclonal antibody, which binds to DEAH-Box Helicase 16 (DHX16). The antibody can be used for immunoassay techniques, such as Dot, ICC.
See all DHX16 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2268C5_2a
Antibody Isotype
IgG1
Application
Dot, ICC

Basic Information

Immunogen
Recombinant Human Deah (Asp-Glu-Ala-His) Box Polypeptide 16 (Dhx16)
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
DEAH (Asp-Glu-Ala-His) box polypeptide 16
Introduction
DHX16 is a DEAD box protein, which is a functional homolog of fission yeast Prp8 protein involved in cell cycle progression. DHX16 is mapped to the MHC region on chromosome 6p21.3, a region where many malignant, genetic and autoimmune disease genes are linked. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division.
Entrez Gene ID
8449
UniProt ID
O60231
Alternative Names
DEAH-Box Helicase 16; DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 16; DEAH (Asp-Glu-Ala-His) Box Polypeptide 16; ATP-Dependent RNA Helicase #3; DEAH-Box Protein 16; DDX16; DBP2; Putative Pre-MRNA-Splicing Factor ATP-Dependent RNA Helicase DHX16; DEAD/H Box 16;
Function
Required for pre-mRNA splicing as component of the spliceosome (PubMed:20423332, PubMed:20841358, PubMed:25296192, PubMed:29360106).

Contributes to pre-mRNA splicing after spliceosome formation and prior to the first transesterification reaction.
Biological Process
mRNA splicing, via spliceosome Source: UniProtKB
RNA splicing Source: ProtInc
Cellular Location
Nucleus; Nucleoplasm
Involvement in disease
Neuromuscular oculoauditory syndrome (NMOAS):
An autosomal dominant neuromuscular disorder characterized by variable features including myopathy, neuropathy, hypotonia, joint contractures, growth delay, chorioretinal lacunae, sensorineuronal deafness, agenesis of the corpus callosum, and seizures.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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