Mouse Anti-DHX16 Recombinant Antibody (2268C5_2a) (CBMAB-D0847-YC)

Name: Mouse Anti-DHX16 Recombinant Antibody (2268C5_2a)
SKU: CBMAB-D0847-YC
Rating: 5 (1 reviews)

See all DHX16 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

2268C5_2a

Application

Dot, ICC

Immunogen

Recombinant Human Deah (Asp-Glu-Ala-His) Box Polypeptide 16 (Dhx16)

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

DEAH (Asp-Glu-Ala-His) box polypeptide 16

Introduction

DHX16 is a DEAD box protein, which is a functional homolog of fission yeast Prp8 protein involved in cell cycle progression. DHX16 is mapped to the MHC region on chromosome 6p21.3, a region where many malignant, genetic and autoimmune disease genes are linked. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division.

Entrez Gene ID

8449

UniProt ID

O60231

Alternative Names

DEAH-Box Helicase 16; DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 16; DEAH (Asp-Glu-Ala-His) Box Polypeptide 16; ATP-Dependent RNA Helicase #3; DEAH-Box Protein 16; DDX16; DBP2; Putative Pre-MRNA-Splicing Factor ATP-Dependent RNA Helicase DHX16; DEAD/H Box 16;

Function

Required for pre-mRNA splicing as component of the spliceosome (PubMed:20423332, PubMed:20841358, PubMed:25296192, PubMed:29360106).

Contributes to pre-mRNA splicing after spliceosome formation and prior to the first transesterification reaction.

Biological Process

mRNA splicing, via spliceosome Source: UniProtKB
RNA splicing Source: ProtInc

Cellular Location

Nucleus; Nucleoplasm

Involvement in disease

Neuromuscular oculoauditory syndrome (NMOAS):
An autosomal dominant neuromuscular disorder characterized by variable features including myopathy, neuropathy, hypotonia, joint contractures, growth delay, chorioretinal lacunae, sensorineuronal deafness, agenesis of the corpus callosum, and seizures.

Hage, A., Bharaj, P., van Tol, S., Giraldo, M. I., Gonzalez-Orozco, M., Valerdi, K. M., ... & Rajsbaum, R. (2022). The RNA helicase DHX16 recognizes specific viral RNA to trigger RIG-I-dependent innate antiviral immunity. Cell reports, 38(10), 110434.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-DHX16 Recombinant Antibody (2268C5_2a)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-DHX16 Recombinant Antibody (D0847) (CAT#: V2LY-0425-LY286)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry