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Mouse Anti-DHX29 Recombinant Antibody (2269C1) (CBMAB-D0849-YC)

Provided herein is a Mouse monoclonal antibody, which binds to DExH-Box Helicase 29 (DHX29). The antibody can be used for immunoassay techniques, such as Dot, FC, ICC, IP, WB.
See all DHX29 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2269C1
Antibody Isotype
IgG1
Application
Dot, FC, ICC, IP, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
DExH-Box Helicase 29
Introduction
DHX29 belongs to the DEAH (Asp-Glu-Ala-His) subfamily of proteins, part of the DEAD (Asp-Glu-Ala-Asp) box family of RNA helicases. The encoded protein functions in translation initiation, and is specifically required for ribosomal scanning across stable mRNA secondary structures during initiation codon selection. This protein may also play a role in sensing virally derived cytosolic nucleic acids. Knockdown of this gene results in reduced protein translation and impaired proliferation of cancer cells.
Entrez Gene ID
54505
UniProt ID
Q7Z478
Alternative Names
DExH-Box Helicase 29; DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 29; Nucleic Acid Helicase DDXx; DEAH-Box Helicase 29; DEAH Box Protein 29; DDX29;
Function
ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity.
Biological Process
Formation of translation preinitiation complex Source: CACAO
Positive regulation of translational initiation Source: UniProtKB-UniRule
Ribosome assembly Source: CACAO
Cellular Location
Cytoplasm
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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