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DHX29

This gene encodes a member of the DEAH (Asp-Glu-Ala-His) subfamily of proteins, part of the DEAD (Asp-Glu-Ala-Asp) box family of RNA helicases. The encoded protein functions in translation initiation, and is specifically required for ribosomal scanning across stable mRNA secondary structures during initiation codon selection. This protein may also play a role in sensing virally derived cytosolic nucleic acids. Knockdown of this gene results in reduced protein translation and impaired proliferation of cancer cells. [provided by RefSeq, Sep 2016]

Full Name

DExH-Box Helicase 29

Function

ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity.

Biological Process

Formation of translation preinitiation complex Source: CACAO
Positive regulation of translational initiation Source: UniProtKB-UniRule
Ribosome assembly Source: CACAO

Cellular Location

Cytoplasm

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Anti-DHX29 antibodies

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Mouse Anti-DHX29 Recombinant Antibody (D0850) (V2LY-0425-LY288)

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Target: DHX29

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: D0850

Application*: IP, WB, F

Mouse Anti-DHX29 Recombinant Antibody (D0849) (V2LY-0425-LY287)

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Target: DHX29

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Mouse, Rat

Clone: D0849

Application*: WB, IP, IF, E

Rabbit Anti-DHX29 Recombinant Antibody (D19E10) (CBMAB-D0850-YC)

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Target: DHX29

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: D19E10

Application*: IP, WB

Mouse Anti-DHX29 Recombinant Antibody (2269C1) (CBMAB-D0849-YC)

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Target: DHX29

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 2269C1

Application*: DB, F, IC, IP, WB

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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