Mouse Anti-DIRAS2 Recombinant Antibody (10H1) (V2LY-0425-LY361)

Name: Mouse Anti-DIRAS2 Recombinant Antibody (10H1)
SKU: V2LY-0425-LY361
Rating: 5 (1 reviews)

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Summary

Host Animal

Mouse

Specificity

Human, Mouse, Rat

Clone

10H1

Antibody Isotype

IgG2b

Application

Basic Information

Immunogen

Human recombinant protein fragment corresponding to amino acids 1-196 of human DIRAS2 produced in E.coli.

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG2b

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:2,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

BSA & Glycerol & PBS

Preservative

Sodium Azide

Concentration

1 mg/ml

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

DIRAS Family GTPase 2

Entrez Gene ID

54769

UniProt ID

Q96HU8

Function

Displays low GTPase activity and exists predominantly in the GTP-bound form.

Biological Process

Signal transduction Source: InterPro

Cellular Location

Cell membrane

More Infomation

References

Ying, K., Wang, C., Liu, S., Kuang, Y., Tao, Q., & Hu, X. (2022). Diverse Ras-related GTPase DIRAS2, downregulated by PSMD2 in a proteasome-mediated way, inhibits colorectal cancer proliferation by blocking NF-κB signaling. International Journal of Biological Sciences, 18(3), 1039.

Rothhammer-Hampl, T., Liesenberg, F., Hansen, N., Hoja, S., Delic, S., Reifenberger, G., & Riemenschneider, M. J. (2021). Frequent Epigenetic Inactivation of DIRAS-1 and DIRAS-2 Contributes to Chemo-Resistance in Gliomas. Cancers, 13(20), 5113.

Li, X., Liu, S., Fang, X., He, C., & Hu, X. (2019). The mechanisms of DIRAS family members in role of tumor suppressor. Journal of cellular physiology, 234(5), 5564-5577.

Sutton, M. N., Yang, H., Huang, G. Y., Fu, C., Pontikos, M., Wang, Y., ... & Bast Jr, R. C. (2018). RAS-related GTPases DIRAS1 and DIRAS2 induce autophagic cancer cell death and are required for autophagy in murine ovarian cancer cells. Autophagy, 14(4), 637-653.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Alternative Versions

Mouse Anti-DIRAS2 Recombinant Antibody (10H1)

Related Products

Mouse Anti-DIRAS2 Recombinant Antibody (10H1)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Datasheet
SDS
Request for COA

Request bulk or custom quote Online Inquiry
Second antibody and isotype control

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