Mouse Anti-DIS3L2 Recombinant Antibody (6C7B2) (CBMAB-D0940-YC)

Name: Mouse Anti-DIS3L2 Recombinant Antibody (6C7B2)
SKU: CBMAB-D0940-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

6C7B2

Application

WB, IHC-P, FC

Specificity

Human

Antibody Isotype

IgG1

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

DIS3 LIKE 3'-5' EXORIBONUCLEASE 2

Introduction

DIS3L2 is similar in sequence to 3'/5' exonucleolytic subunits of the RNA exosome. The exosome is a large multimeric ribonucleotide complex responsible for degrading various RNA substrates. Several transcript variants, some protein-coding and some not, have been found for this gene.

Entrez Gene ID

129563

UniProt ID

Q8IYB7

Alternative Names

DIS3 Like 3'-5' Exoribonuclease 2; DIS3 Like 3-5 Exoribonuclease 2; Family With Sequence Similarity 6, Member A; HDIS3L2; FAM6A; DIS3 Mitotic Control Homolog (S. Cerevisiae)-Like 2;

Function

3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation.

Biological Process

Cell division Source: UniProtKB-KW
miRNA catabolic process Source: UniProtKB
Mitotic cell cycle Source: UniProtKB
Mitotic sister chromatid separation Source: UniProtKB
mRNA catabolic process Source: GO_Central
Negative regulation of cell population proliferation Source: UniProtKB
Nuclear-transcribed mRNA catabolic process, exonucleolytic Source: UniProtKB
Nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' Source: InterPro
Polyuridylation-dependent mRNA catabolic process Source: UniProtKB
Stem cell population maintenance Source: UniProtKB

Cellular Location

Cytoplasm; P-body

Involvement in disease

Perlman syndrome (PRLMNS):
An autosomal recessive congenital overgrowth syndrome. Affected children are large at birth, are hypotonic, and show organomegaly, characteristic facial dysmorphisms (inverted V-shaped upper lip, prominent forehead, deep-set eyes, broad and flat nasal bridge, and low-set ears), renal anomalies (nephromegaly and hydronephrosis), frequent neurodevelopmental delay, and high neonatal mortality. Perlman syndrome is associated with a high risk of Wilms tumor. Histologic examination of the kidneys in affected children shows frequent nephroblastomatosis, which is a precursor lesion for Wilms tumor.

Ballou, E. R., Cook, A. G., & Wallace, E. W. (2021). Repeated evolution of inactive pseudonucleases in a fungal branch of the Dis3/RNase II family of nucleases. Molecular Biology and Evolution, 38(5), 1837-1846.

Towler, B. P., Pashler, A. L., Haime, H. J., Przybyl, K. M., Viegas, S. C., Matos, R. G., ... & Newbury, S. F. (2020). Dis3L2 regulates cell proliferation and tissue growth through a conserved mechanism. PLoS genetics, 16(12), e1009297.

Luan, S., Luo, J., Liu, H., & Li, Z. (2019). Regulation of RNA decay and cellular function by 3′-5′ exoribonuclease DIS3L2. RNA biology, 16(2), 160-165.

Xing, S., Li, Z., Ma, W., He, X., Shen, S., Wei, H., ... & Zhang, H. (2019). DIS3L2 promotes progression of hepatocellular carcinoma via hnRNP U-mediated alternative splicing. Cancer Research, 79(19), 4923-4936.

Saramago, M., Costa, P. J. D., Viegas, S. C., & Arraiano, C. M. (2019). The implication of mRNA degradation disorders on human DISease: focus on DIS3 and DIS3-like enzymes. The mRNA Metabolism in Human Disease, 85-98.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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