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Mouse Anti-DIS3L2 Recombinant Antibody (6C7B2) (CBMAB-D0940-YC)

Provided herein is a Mouse monoclonal antibody, which binds to DIS3 Like 3'-5' Exoribonuclease 2 (DIS3L2). The antibody can be used for immunoassay techniques, such as WB, IHC-P, FC.
See all DIS3L2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
6C7B2
Antibody Isotype
IgG1
Application
WB, IHC-P, FC

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
DIS3 LIKE 3'-5' EXORIBONUCLEASE 2
Introduction
DIS3L2 is similar in sequence to 3'/5' exonucleolytic subunits of the RNA exosome. The exosome is a large multimeric ribonucleotide complex responsible for degrading various RNA substrates. Several transcript variants, some protein-coding and some not, have been found for this gene.
Entrez Gene ID
129563
UniProt ID
Q8IYB7
Alternative Names
DIS3 Like 3'-5' Exoribonuclease 2; DIS3 Like 3-5 Exoribonuclease 2; Family With Sequence Similarity 6, Member A; HDIS3L2; FAM6A; DIS3 Mitotic Control Homolog (S. Cerevisiae)-Like 2;
Function
3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation.
Biological Process
Cell division Source: UniProtKB-KW
miRNA catabolic process Source: UniProtKB
Mitotic cell cycle Source: UniProtKB
Mitotic sister chromatid separation Source: UniProtKB
mRNA catabolic process Source: GO_Central
Negative regulation of cell population proliferation Source: UniProtKB
Nuclear-transcribed mRNA catabolic process, exonucleolytic Source: UniProtKB
Nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' Source: InterPro
Polyuridylation-dependent mRNA catabolic process Source: UniProtKB
Stem cell population maintenance Source: UniProtKB
Cellular Location
Cytoplasm; P-body
Involvement in disease
Perlman syndrome (PRLMNS):
An autosomal recessive congenital overgrowth syndrome. Affected children are large at birth, are hypotonic, and show organomegaly, characteristic facial dysmorphisms (inverted V-shaped upper lip, prominent forehead, deep-set eyes, broad and flat nasal bridge, and low-set ears), renal anomalies (nephromegaly and hydronephrosis), frequent neurodevelopmental delay, and high neonatal mortality. Perlman syndrome is associated with a high risk of Wilms tumor. Histologic examination of the kidneys in affected children shows frequent nephroblastomatosis, which is a precursor lesion for Wilms tumor.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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