Mouse Anti-DKK1 Recombinant Antibody (CBT444) (V2LY-0625-LY3521)

Dickkopf WNT Signaling Pathway Inhibitor 1

Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6 (PubMed:22000856).

DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (PubMed:17143291).

Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity (By similarity).

Learning or memory Source: ARUK-UCL
Limb development Source: UniProtKB
Modulation of age-related behavioral decline Source: ARUK-UCL
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of canonical Wnt signaling pathway Source: ParkinsonsUK-UCL
Negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment Source: BHF-UCL
Negative regulation of cardiac muscle cell differentiation Source: BHF-UCL
Negative regulation of mesodermal cell fate specification Source: BHF-UCL
Negative regulation of ossification Source: UniProtKB
Negative regulation of pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
Negative regulation of peptidyl-serine phosphorylation Source: BHF-UCL
Negative regulation of protein binding Source: ParkinsonsUK-UCL
Negative regulation of transcription by RNA polymerase II Source: BHF-UCL
Negative regulation of Wnt-Frizzled-LRP5/6 complex assembly Source: ParkinsonsUK-UCL
Negative regulation of Wnt signaling pathway Source: UniProtKB
Positive regulation of cell death Source: ARUK-UCL
Positive regulation of gene expression Source: ARUK-UCL
Positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway Source: BHF-UCL
Positive regulation of JUN kinase activity Source: ARUK-UCL
Positive regulation of neuron death Source: ARUK-UCL
Positive regulation of tau-protein kinase activity Source: ARUK-UCL
Positive regulation of Wnt signaling pathway, calcium modulating pathway Source: ARUK-UCL
Positive regulation of Wnt signaling pathway, planar cell polarity pathway Source: ARUK-UCL
Regulation of dopaminergic neuron differentiation Source: ParkinsonsUK-UCL
Regulation of endodermal cell fate specification Source: BHF-UCL
Regulation of receptor internalization Source: BHF-UCL
Synapse pruning Source: ParkinsonsUK-UCL
Wnt signaling pathway Source: UniProtKB-KW

Secreted