Mouse Anti-DKK4 Recombinant Antibody (CBYCD-294) (CBMAB-D1001-YC)

Name: Mouse Anti-DKK4 Recombinant Antibody (CBYCD-294)
SKU: CBMAB-D1001-YC
Rating: 5 (1 reviews)

See all DKK4 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYCD-294

Application

WB, ELISA

Immunogen

Mouse myeloma cell line NS0-derived recombinant human Dkk-4, Leu19-Leu224, Accession # Q9UBT3

Specificity

Human

Antibody Isotype

IgG2b

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Dickkopf WNT Signaling Pathway Inhibitor 4

Introduction

DKK4 is a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. Activity of this protein is modulated by binding to the Wnt co-receptor and the co-factor kremen 2.

Entrez Gene ID

27121

UniProt ID

Q9UBT3

Alternative Names

Dickkopf WNT Signaling Pathway Inhibitor 4; Dickkopf-4; HDkk-4; DKK-4; Dickkopf (Xenopus Laevis) Homolog 4; Dickkopf Homolog 4 (Xenopus Laevis); Dickkopf-Related Protein 4;

Function

Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).

Biological Process

Negative regulation of canonical Wnt signaling pathway Source: GO_Central
Negative regulation of hair follicle placode formation Source: Ensembl
Negative regulation of Wnt signaling pathway Source: UniProtKB
Wnt signaling pathway Source: UniProtKB-KW

Cellular Location

Secreted

PTM

Appears to be not glycosylated.
Can be proteolytically processed by a furin-like protease.

Hu, Y., Liu, M., Xu, S., Li, S., Yang, M., Su, T., ... & Peng, H. (2020). The clinical significance of dickkopf wnt signaling pathway inhibitor gene family in head and neck squamous cell carcinoma. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research, 26, e927368-1.

Patel, S., Barkell, A. M., Gupta, D., Strong, S. L., Bruton, S., Muskett, F. W., ... & Carr, M. D. (2018). Structural and functional analysis of Dickkopf 4 (Dkk4): new insights into Dkk evolution and regulation of Wnt signaling by Dkk and Kremen proteins. Journal of Biological Chemistry, 293(31), 12149-12166.

Cai, X., Yao, Z., Li, L., & Huang, J. (2018). Role of DKK4 in tumorigenesis and tumor progression. International journal of biological sciences, 14(6), 616.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-DKK4 Recombinant Antibody (CBYCD-294)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Mouse Anti-DKK4 Recombinant Antibody (CBYCD-294) (CAT#: V2LY-0425-LY406)

Related Products

Mouse Anti-DKK4 Recombinant Antibody (CBYCD-294) (CAT#: V2LY-0425-LY406)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry