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Mouse Anti-DKK4 Recombinant Antibody (CBYCD-294) (CBMAB-D1001-YC)

Provided herein is a Mouse monoclonal antibody, which binds to Dickkopf WNT Signaling Pathway Inhibitor 4 (DKK4). The antibody can be used for immunoassay techniques, such as WB, ELISA.
See all DKK4 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYCD-294
Antibody Isotype
IgG2b
Application
WB, ELISA

Basic Information

Immunogen
Mouse myeloma cell line NS0-derived recombinant human Dkk-4, Leu19-Leu224, Accession # Q9UBT3
Specificity
Human
Antibody Isotype
IgG2b
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Dickkopf WNT Signaling Pathway Inhibitor 4
Introduction
DKK4 is a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. Activity of this protein is modulated by binding to the Wnt co-receptor and the co-factor kremen 2.
Entrez Gene ID
27121
UniProt ID
Q9UBT3
Alternative Names
Dickkopf WNT Signaling Pathway Inhibitor 4; Dickkopf-4; HDkk-4; DKK-4; Dickkopf (Xenopus Laevis) Homolog 4; Dickkopf Homolog 4 (Xenopus Laevis); Dickkopf-Related Protein 4;
Function
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).
Biological Process
Negative regulation of canonical Wnt signaling pathway Source: GO_Central
Negative regulation of hair follicle placode formation Source: Ensembl
Negative regulation of Wnt signaling pathway Source: UniProtKB
Wnt signaling pathway Source: UniProtKB-KW
Cellular Location
Secreted
PTM
Appears to be not glycosylated.
Can be proteolytically processed by a furin-like protease.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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