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Mouse Anti-DKK4 Recombinant Antibody (CBYCD-294) (V2LY-0425-LY406)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYCD-294
Antibody Isotype
IgG1, κ
Application
ELISA

Basic Information

Immunogen
Recombinant Human Dkk-4 (Gln107-His212).
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal Antibody

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Glycerol & PBS
Preservative
Sodium Azide
Concentration
1 mg/ml
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Dickkopf WNT Signaling Pathway Inhibitor 4
Entrez Gene ID
27121
UniProt ID
Q9UBT3
Function
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).
Biological Process
Negative regulation of canonical Wnt signaling pathway Source: GO_Central
Negative regulation of hair follicle placode formation Source: Ensembl
Negative regulation of Wnt signaling pathway Source: UniProtKB
Wnt signaling pathway Source: UniProtKB-KW
Cellular Location
Secreted
PTM
Appears to be not glycosylated.
Can be proteolytically processed by a furin-like protease.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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