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Mouse Anti-DLST Recombinant Antibody (4D7) (CBMAB-D1107-YC)

Provided herein is a Mouse monoclonal antibody, which binds to Dihydrolipoamide S-Succinyltransferase (DLST). The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all DLST antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4D7
Antibody Isotype
IgG2b, κ
Application
ELISA, WB

Basic Information

Immunogen
DLST (NP_001924, 1 a.a. ~ 99 a.a) partial recombinant protein with GST tag. The immunogen sequence: MLSRSRCVSR AFSRSLSAFQ KGNCPLGRRS LPGVSLCQGP GYPNSRKVVI NNSVFSVRFF RTTAVCKDDL VTVKTPAFAE SVTEGDVRWE KAVGDTVAE
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Dihydrolipoamide S-Succinyltransferase
Introduction
DLST is a mitochondrial protein that belongs to the 2-oxoacid dehydrogenase family. This protein is one of the three components (the E2 component) of the 2-oxoglutarate dehydrogenase complex that catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). Alternatively spliced transcript variants have been found for this gene.
Entrez Gene ID
1743
UniProt ID
P36957
Alternative Names
Dihydrolipoamide S-Succinyltransferase; Dihydrolipoamide S-Succinyltransferase (E2 Component Of 2-Oxo-Glutarate Complex); EC 2.3.1.61; OGDC-E2; DLTS; E2K;
Function
Dihydrolipoamide succinyltransferase (E2) component of the 2-oxoglutarate dehydrogenase complex. The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion (PubMed:29211711, PubMed:30929736).

A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A (PubMed:29211711).
Biological Process
2-oxoglutarate metabolic process Source: UniProtKB
Generation of precursor metabolites and energy Source: ProtInc
Histone succinylation Source: UniProtKB
L-lysine catabolic process to acetyl-CoA via saccharopine Source: UniProtKB-UniPathway
Succinyl-CoA metabolic process Source: UniProtKB
Tricarboxylic acid cycle Source: UniProtKB
Cellular Location
Mitochondrion matrix; Nucleus. Mainly localizes in the mitochondrion. A small fraction localizes to the nucleus, where the 2-oxoglutarate dehydrogenase complex is required for histone succinylation.
Involvement in disease
Paragangliomas 7 (PGL7):
An autosomal dominant tumor predisposition syndrome characterized by adult-onset development of paragangliomas, neural crest tumors usually derived from the chromoreceptor tissue of a paraganglion. PGL7 tumors are generally benign, tend to be abdominal, and often secrete normetanephrine.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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