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Mouse Anti-Dmap1 Recombinant Antibody (B-10) (CBMAB-D1160-YC)

Provided herein is a Mouse monoclonal antibody, which binds to DNA Methyltransferase 1 Associated Protein 1 (Dmap1). The antibody can be used for immunoassay techniques, such as WB, IP, IF, ELISA.
See all Dmap1 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
B-10
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
DNA Methyltransferase 1 Associated Protein 1
Introduction
Dmap1 is a subunit of several, distinct complexes involved in the repression or activation of transcription. The encoded protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA methyltransferase 1. During late S phase, histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication. The encoded protein is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among others. Alternatively spliced transcript variants encoding the same protein have been described.
Entrez Gene ID
Human55929
Mouse66233
Rat298447
UniProt ID
HumanQ9NPF5
MouseQ9JI44
RatQ568Y6
Alternative Names
DNA Methyltransferase 1 Associated Protein 1; DNMAP1; DNA Methyltransferase 1-Associated Protein 1; DNMT1 Associated Protein 1; DNMT1-Associated Protein 1; KIAA1425;
Function
Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX-mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Participates in the nuclear localization of URI1 and increases its transcriptional corepressor activity.
Biological Process
DNA methylation Source: UniProtKB
DNA repair Source: InterPro
Histone exchange Source: GO_Central
Histone H2A acetylation Source: UniProtKB
Histone H4 acetylation Source: UniProtKB
Negative regulation of transcription, DNA-templated Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Positive regulation of protein import into nucleus Source: UniProtKB
Regulation of growth Source: UniProtKB-KW
Response to ethanol Source: Ensembl
Cellular Location
Cytoplasm; Nucleus. Targeted to replication foci throughout S phase by DNMT1.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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