Mouse Anti-DNAI2 (AA 1-594) Recombinant Antibody (CBFYC-2588) (CBMAB-C2662-FY)

Name: Mouse Anti-DNAI2 (AA 1-594) Recombinant Antibody (CBFYC-2588)
SKU: CBMAB-C2662-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYC-2588

Application

ELISA, ICC, WB

Specificity

Human

Antibody Isotype

IgG2a

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Concentration

0.5 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 1-594

More Infomation

Target

Full Name

Dynein Axonemal Intermediate Chain 2

Introduction

The protein encoded by this gene belongs to the dynein intermediate chain family, and is part of the dynein complex of respiratory cilia and sperm flagella. Mutations in this gene are associated with primary ciliary dyskinesia type 9. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

Entrez Gene ID

64446

UniProt ID

Q9GZS0

Alternative Names

Dynein Axonemal Intermediate Chain 2; Dynein, Axonemal, Intermediate Polypeptide 2; Dynein Intermediate Chain 2, Axonemal; Axonemal Dynein Intermediate Chain 2; Dynein Intermediate Chain 2; CILD9; DIC2

Function

Part of the dynein complex of respiratory cilia.

Biological Process

Cilium assembly Source: MGI
Cilium movement Source: SYSCILIA_CCNET
Determination of left/right symmetry Source: SYSCILIA_CCNET
Microtubule-based movement Source: GO_Central
Outer dynein arm assembly Source: SYSCILIA_CCNET

Cellular Location

Cilium axoneme; Dynein axonemal particle

Involvement in disease

Ciliary dyskinesia, primary, 9 (CILD9):
A disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails. Half of the patients exhibit randomization of left-right body asymmetry and situs inversus, due to dysfunction of monocilia at the embryonic node. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome.

Lv, Y., Liu, Y., Wang, Y., Kong, F., Pang, Q., & Hu, G. (2021). CCDC114, DNAI2 and TOP2A involves in the effects of tibolone treatment on postmenopausal endometrium. BMC Women's Health, 21(1), 1-10.

Rocca, M. S., Piatti, G., Michelucci, A., Guazzo, R., Bertini, V., Vinanzi, C., ... & Foresta, C. (2020). A novel genetic variant in DNAI2 detected by custom gene panel in a newborn with Primary Ciliary Dyskinesia: case report. BMC medical genetics, 21(1), 1-6.

Rocca, M., Vinanzi, C., Michelucci, A., Caligo, M., Valetto, A., De Santi, M., ... & Foresta, C. (2020, June). A new genetic variants in DNAI2 detected by target sequencing in a newborn with primary ciliary dyskinesia. In The European Human Genetic virtual Conference.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Mouse Anti-DNAI2 Recombinant Antibody (CBFYC-2588) (CAT#: V2LY-0425-LY608)

Antibody Pairs

DNAI2 Matched Antibody Pair (343) (CAT#: APMAB-343LY)

DNAI2 Matched Antibody Pair (344) (CAT#: APMAB-344LY)

Related Products

DNAI2 Matched Antibody Pair (343) (CAT#: APMAB-343LY)

Mouse Anti-DNAI2 Recombinant Antibody (CBXC-0640) (CAT#: V2LY-0425-LY609)

Mouse Anti-DNAI2 Recombinant Antibody (CBFYC-2588) (CAT#: V2LY-0425-LY608)

DNAI2 Matched Antibody Pair (344) (CAT#: APMAB-344LY)

Mouse Anti-DNAI2 Recombinant Antibody (CBXC-0640) (CAT#: CBMAB-C5725-CQ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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