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Mouse Anti-DNAI2 Recombinant Antibody (CBXC-0640) (CBMAB-C5725-CQ)

This product is a mouse antibody that recognizes DNAI2. The antibody CBXC-0640 can be used for immunoassay techniques such as: ELISA, IF, WB.
See all DNAI2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXC-0640
Antibody Isotype
IgG2a, κ
Application
ELISA, IF, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Dynein Axonemal Intermediate Chain 2
Introduction
The protein encoded by this gene belongs to the dynein intermediate chain family, and is part of the dynein complex of respiratory cilia and sperm flagella. Mutations in this gene are associated with primary ciliary dyskinesia type 9. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Entrez Gene ID
64446
UniProt ID
Q9GZS0
Alternative Names
Dynein Axonemal Intermediate Chain 2; Dynein, Axonemal, Intermediate Polypeptide 2; Dynein Intermediate Chain 2, Axonemal; Axonemal Dynein Intermediate Chain 2; Dynein Intermediate Chain 2; CILD9; DIC2;
Function
Part of the dynein complex of respiratory cilia.
Biological Process
Cilium assembly Source: MGI
Cilium movement Source: SYSCILIA_CCNET
Determination of left/right symmetry Source: SYSCILIA_CCNET
Microtubule-based movement Source: GO_Central
Outer dynein arm assembly Source: SYSCILIA_CCNET
Cellular Location
Cilium axoneme; Dynein axonemal particle
Involvement in disease
Ciliary dyskinesia, primary, 9 (CILD9):
A disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails. Half of the patients exhibit randomization of left-right body asymmetry and situs inversus, due to dysfunction of monocilia at the embryonic node. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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