Mouse Anti-DNAJA3 Recombinant Antibody (CBYJT-1186) (V2LY-0425-LY618)

DnaJ Heat Shock Protein Family (Hsp40) Member A3

Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway.

Activation-induced cell death of T cells Source: Ensembl
Activation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
Cell aging Source: Ensembl
Mitochondrial DNA replication Source: Ensembl
Mitochondrion organization Source: GO_Central
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of cell population proliferation Source: UniProtKB
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
Negative regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
Negative regulation of interferon-gamma-mediated signaling pathway Source: UniProtKB
Negative regulation of NF-kappaB transcription factor activity Source: UniProtKB
Negative regulation of programmed cell death Source: Ensembl
Negative regulation of protein kinase activity Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Neuromuscular junction development Source: UniProtKB
Positive regulation of apoptotic process Source: UniProtKB
Positive regulation of protein ubiquitination Source: UniProtKB
Positive regulation of T cell proliferation Source: Ensembl
Protein folding Source: UniProtKB
Protein stabilization Source: UniProtKB
Regulation of apoptotic process Source: GO_Central
Response to heat Source: InterPro
Response to interferon-gamma Source: UniProtKB
Skeletal muscle acetylcholine-gated channel clustering Source: UniProtKB
Small GTPase mediated signal transduction Source: Ensembl
T cell differentiation in thymus Source: Ensembl

Mitochondrion matrix; Cytosol; Postsynaptic cell membrane. Recruited to the postsynaptic cell membrane of the neuromuscular junction through interaction with MUSK.

Tyrosine phosphorylated.