Mouse Anti-DNAJB2 Recombinant Antibody (1B7) (V2LY-0425-LY632)
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Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
In parallel, also contributes to the ubiquitin-dependent proteasomal degradation of misfolded proteins (PubMed:15936278, PubMed:21625540).
Thereby, may regulate the aggregation and promote the functional recovery of misfolded proteins like HTT, MC4R, PRKN, RHO and SOD1 and be crucial for many biological processes (PubMed:12754272, PubMed:20889486, PubMed:21719532, PubMed:22396390, PubMed:24023695).
Isoform 1 which is localized to the endoplasmic reticulum membranes may specifically function in ER-associated protein degradation of misfolded proteins (PubMed:15936278).
Negative regulation of cell growth Source: UniProtKB
Negative regulation of cell population proliferation Source: UniProtKB
Negative regulation of inclusion body assembly Source: BHF-UCL
Negative regulation of protein binding Source: UniProtKB
Negative regulation of protein deubiquitination Source: BHF-UCL
Neuron cellular homeostasis Source: ARUK-UCL
Positive regulation of ATPase activity Source: UniProtKB
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: BHF-UCL
Positive regulation of protein ubiquitination Source: BHF-UCL
Proteasome-mediated ubiquitin-dependent protein catabolic process Source: UniProtKB
Protein refolding Source: UniProtKB
Regulation of chaperone-mediated protein folding Source: UniProtKB
Regulation of protein localization Source: ParkinsonsUK-UCL
Regulation of protein ubiquitination Source: UniProtKB
Response to unfolded protein Source: ProtInc
Ubiquitin-dependent ERAD pathway Source: BHF-UCL
Isoform 2: Cytoplasm; Nucleus
An autosomal recessive neurologic disorder characterized by young adult onset of slowly progressive distal muscle weakness and atrophy resulting in gait impairment and loss of reflexes due to impaired function of motor nerves. Sensation and cognition are not impaired.
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols
Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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