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Mouse Anti-DNAJB9 Recombinant Antibody (CBFYE-0352) (V2LY-0425-LY643)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBFYE-0352
Antibody Isotype
IgG2a, κ
Application
ELISA, IF

Basic Information

Immunogen
DNAJB9 (aa114-223) partial recombinant protein.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
IF(ICC)10 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
None
Concentration
Batch dependent
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
DnaJ (Hsp40) homolog, subfamily B, member 9
Entrez Gene ID
4189
UniProt ID
Q9UBS3
Function
Co-chaperone for Hsp70 protein HSPA5/BiP that acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR) (By similarity).

J domain-containing co-chaperones stimulate the ATPase activity of Hsp70 proteins and are required for efficient substrate recognition by Hsp70 proteins (PubMed:18400946).

In the unstressed endoplasmic reticulum, interacts with the luminal region of ERN1/IRE1 and selectively recruits HSPA5/BiP: HSPA5/BiP disrupts the dimerization of the active ERN1/IRE1 luminal region, thereby inactivating ERN1/IRE1 (By similarity).

Also involved in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Required for survival of B-cell progenitors and normal antibody production (By similarity).
Biological Process
B cell differentiation Source: UniProtKB
Negative regulation of IRE1-mediated unfolded protein response Source: UniProtKB
Positive regulation of immunoglobulin production Source: UniProtKB
Response to endoplasmic reticulum stress Source: UniProtKB
Response to unfolded protein Source: UniProtKB-KW
Ubiquitin-dependent ERAD pathway Source: UniProtKB
Cellular Location
Endoplasmic reticulum lumen
More Infomation

Kim, H. Y., Kim, Y. M., & Hong, S. (2021). DNAJB9 suppresses the metastasis of triple-negative breast cancer by promoting FBXO45-mediated degradation of ZEB1. Cell Death & Disease, 12(5), 1-12.

Said, S. M., Rocha, A. B., Royal, V., Valeri, A. M., Larsen, C. P., Theis, J. D., ... & Nasr, S. H. (2021). Immunoglobulin-negative DNAJB9-associated fibrillary glomerulonephritis: a report of 9 cases. American Journal of Kidney Diseases, 77(3), 454-458.

Wang, D., Zeng, T., Lin, Z., Yan, L., Wang, F., Tang, L., ... & Yang, M. (2020). Long non-coding RNA SNHG5 regulates chemotherapy resistance through the miR-32/DNAJB9 axis in acute myeloid leukemia. Biomedicine & Pharmacotherapy, 123, 109802.

Sun, F., Liao, Y., Qu, X., Xiao, X., Hou, S., Chen, Z., ... & Fu, S. (2020). Hepatic DNAJB9 drives anabolic biasing to reduce steatosis and obesity. Cell Reports, 30(6), 1835-1847.

Lee, H. J., Jung, Y. J., Lee, S., Kim, J. I., & Han, J. A. (2020). DNAJB9 Inhibits p53-dependent oncogene-induced senescence and induces cell transformation. Molecules and cells, 43(4), 397.

Said, S. M., Leung, N., Alexander, M. P., Cornell, L. D., Fidler, M. E., Grande, J. P., ... & Nasr, S. H. (2020). DNAJB9-positive monotypic fibrillary glomerulonephritis is not associated with monoclonal gammopathy in the vast majority of patients. Kidney international, 98(2), 498-504.

Nasr, S. H., Dasari, S., Lieske, J. C., Benson, L. M., Vanderboom, P. M., Holtz-Heppelmann, C. J., ... & Alexander, M. P. (2019). Serum levels of DNAJB9 are elevated in fibrillary glomerulonephritis patients. Kidney international, 95(5), 1269-1272.

Huang, Y., Arora, K., Mun, K. S., Yang, F., Moon, C., Yarlagadda, S., ... & Naren, A. P. (2019). Targeting DNAJB9, a novel ER luminal co-chaperone, to rescue ΔF508-CFTR. Scientific reports, 9(1), 1-11.

Nasr, S. H., Vrana, J. A., Dasari, S., Bridoux, F., Fidler, M. E., Kaaki, S., ... & Alexander, M. P. (2018). DNAJB9 is a specific immunohistochemical marker for fibrillary glomerulonephritis. Kidney international reports, 3(1), 56-64.

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For research use only. Not intended for any clinical use.

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