Sign in or Register   Sign in or Register
  |  

Mouse Anti-DNAJB9 Recombinant Antibody (CBFYE-0352) (CBMAB-E0646-FY)

This product is mouse antibody that recognizes DNAJB9. The antibody CBFYE-0352 can be used for immunoassay techniques such as: ELISA, IF.
See all DNAJB9 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYE-0352
Antibody Isotype
IgG2a, κ
Application
ELISA, IF

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
DnaJ (Hsp40) homolog, subfamily B, member 9
Introduction
This gene is a member of the J protein family. J proteins function in many cellular processes by regulating the ATPase activity of 70 kDa heat shock proteins. This gene is a member of the type 2 subgroup of DnaJ proteins. The encoded protein is localized to the endoplasmic reticulum. This protein is induced by endoplasmic reticulum stress and plays a role in protecting stressed cells from apoptosis.
Entrez Gene ID
4189
UniProt ID
Q9UBS3
Alternative Names
DnaJ Heat Shock Protein Family (Hsp40) Member B9; Microvascular Endothelial Differentiation Gene 1 Protein; Endoplasmic Reticulum DNA J Domain-Containing Protein 4; DnaJ (Hsp40) Homolog, Subfamily B, Member 9; ER-Resident Protein ERdj4; MDG-1; ERdj4
Function
Co-chaperone for Hsp70 protein HSPA5/BiP that acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR) (By similarity).

J domain-containing co-chaperones stimulate the ATPase activity of Hsp70 proteins and are required for efficient substrate recognition by Hsp70 proteins (PubMed:18400946).

In the unstressed endoplasmic reticulum, interacts with the luminal region of ERN1/IRE1 and selectively recruits HSPA5/BiP: HSPA5/BiP disrupts the dimerization of the active ERN1/IRE1 luminal region, thereby inactivating ERN1/IRE1 (By similarity).

Also involved in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Required for survival of B-cell progenitors and normal antibody production (By similarity).
Biological Process
B cell differentiation Source: UniProtKB
Negative regulation of IRE1-mediated unfolded protein response Source: UniProtKB
Positive regulation of immunoglobulin production Source: UniProtKB
Response to endoplasmic reticulum stress Source: UniProtKB
Response to unfolded protein Source: UniProtKB-KW
Ubiquitin-dependent ERAD pathway Source: UniProtKB
Cellular Location
Endoplasmic reticulum lumen

Kim, H. Y., Kim, Y. M., & Hong, S. (2021). DNAJB9 suppresses the metastasis of triple-negative breast cancer by promoting FBXO45-mediated degradation of ZEB1. Cell Death & Disease, 12(5), 1-12.

Said, S. M., Rocha, A. B., Royal, V., Valeri, A. M., Larsen, C. P., Theis, J. D., ... & Nasr, S. H. (2021). Immunoglobulin-negative DNAJB9-associated fibrillary glomerulonephritis: a report of 9 cases. American Journal of Kidney Diseases, 77(3), 454-458.

Wang, D., Zeng, T., Lin, Z., Yan, L., Wang, F., Tang, L., ... & Yang, M. (2020). Long non-coding RNA SNHG5 regulates chemotherapy resistance through the miR-32/DNAJB9 axis in acute myeloid leukemia. Biomedicine & Pharmacotherapy, 123, 109802.

Sun, F., Liao, Y., Qu, X., Xiao, X., Hou, S., Chen, Z., ... & Fu, S. (2020). Hepatic DNAJB9 drives anabolic biasing to reduce steatosis and obesity. Cell Reports, 30(6), 1835-1847.

Lee, H. J., Jung, Y. J., Lee, S., Kim, J. I., & Han, J. A. (2020). DNAJB9 Inhibits p53-dependent oncogene-induced senescence and induces cell transformation. Molecules and cells, 43(4), 397.

Said, S. M., Leung, N., Alexander, M. P., Cornell, L. D., Fidler, M. E., Grande, J. P., ... & Nasr, S. H. (2020). DNAJB9-positive monotypic fibrillary glomerulonephritis is not associated with monoclonal gammopathy in the vast majority of patients. Kidney international, 98(2), 498-504.

Nasr, S. H., Dasari, S., Lieske, J. C., Benson, L. M., Vanderboom, P. M., Holtz-Heppelmann, C. J., ... & Alexander, M. P. (2019). Serum levels of DNAJB9 are elevated in fibrillary glomerulonephritis patients. Kidney international, 95(5), 1269-1272.

Huang, Y., Arora, K., Mun, K. S., Yang, F., Moon, C., Yarlagadda, S., ... & Naren, A. P. (2019). Targeting DNAJB9, a novel ER luminal co-chaperone, to rescue ΔF508-CFTR. Scientific reports, 9(1), 1-11.

Nasr, S. H., Vrana, J. A., Dasari, S., Bridoux, F., Fidler, M. E., Kaaki, S., ... & Alexander, M. P. (2018). DNAJB9 is a specific immunohistochemical marker for fibrillary glomerulonephritis. Kidney international reports, 3(1), 56-64.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-DNAJB9 Recombinant Antibody (CBFYE-0352)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare