Mouse Anti-DNAJC7 Recombinant Antibody (4G6-G3) (V2LY-0425-LY660)

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Basic Information

Host Animal
Mouse
Clone
4G6-G3
Application
ELISA, IF, WB
Immunogen
Full length recombinant DNAJC7.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
IF(ICC)10 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
None
Concentration
Batch dependent
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
DnaJ (Hsp40) homolog, subfamily C, member 7
Entrez Gene ID
UniProt ID
Function
Acts as co-chaperone regulating the molecular chaperones HSP70 and HSP90 in folding of steroid receptors, such as the glucocorticoid receptor and the progesterone receptor. Proposed to act as a recycling chaperone by facilitating the return of chaperone substrates to early stages of chaperoning if further folding is required. In vitro, induces ATP-independent dissociation of HSP90 but not of HSP70 from the chaperone-substrate complexes. Recruits NR1I3 to the cytoplasm (By similarity).
Biological Process
Chaperone cofactor-dependent protein refolding Source: UniProtKB
Protein folding Source: ProtInc
Regulation of cellular response to heat Source: Reactome
Cellular Location
Cytoplasm; Cytoskeleton; Nucleus. Colocalizes with NR1I3 to microtubules.

Dilliott, A. A., Andary, C. M., Stoltz, M., Petropavlovskiy, A. A., Farhan, S. M., & Duennwald, M. L. (2022). DnaJC7 in Amyotrophic Lateral Sclerosis. International Journal of Molecular Sciences, 23(8), 4076.

Tohnai, G., Nakamura, R., Atsuta, N., Nakatochi, M., Hayashi, N., Ito, D., ... & Japanese Consortium for Amyotrophic Lateral Sclerosis Research (JaCALS. (2022). Mutation screening of the DNAJC7 gene in Japanese patients with sporadic amyotrophic lateral sclerosis. Neurobiology of aging, 113, 131-136.

Hou, Z., Wydorski, P. M., Perez, V. A., Mendoza-Oliva, A., Ryder, B. D., Mirbaha, H., ... & Joachimiak, L. A. (2021). DnaJC7 binds natively folded structural elements in tau to inhibit amyloid formation. Nature communications, 12(1), 1-17.

He, J., Ma, X., Yu, W., Tang, L., Fu, J., Liu, X., ... & Fan, D. (2021). Validation of the pathogenic role of rare DNAJC7 variants in Chinese patients with amyotrophic lateral sclerosis. Neurobiology of Aging, 106, 314-e1.

Sun, X., Zhao, X., Liu, Q., Zhang, K., Liu, S., Wang, Z., ... & Zhang, X. (2021). Mutations of DNAJC7 are rare in Chinese amyotrophic lateral sclerosis patients. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 22(3-4), 312-315.

Jih, K. Y., Tsai, P. C., Tsai, Y. S., Liao, Y. C., & Lee, Y. C. (2020). Rapid progressive ALS in a patient with a DNAJC7 loss-of-function mutation. Neurology Genetics, 6(5).

Wang, M., Liu, Z., Yuan, Y., Ni, J., Li, W., Hu, Y., ... & Wang, J. (2020). A novel potentially pathogenic rare variant in the DNAJC7 gene identified in amyotrophic lateral sclerosis patients from Mainland China. Frontiers in Genetics, 821.

Farhan, S. M., Howrigan, D. P., Abbott, L. E., Klim, J. R., Topp, S. D., Byrnes, A. E., ... & Neale, B. M. (2020). Publisher Correction: Exome sequencing in amyotrophic lateral sclerosis implicates a novel gene, DNAJC7, encoding a heat-shock protein. Nature neuroscience, 23(2), 295-295.

Farhan, S. M., Howrigan, D. P., Abbott, L. E., Klim, J. R., Topp, S. D., Byrnes, A. E., ... & Neale, B. M. (2019). Exome sequencing in amyotrophic lateral sclerosis implicates a novel gene, DNAJC7, encoding a heat-shock protein. Nature neuroscience, 22(12), 1966-1974.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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