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Mouse Anti-DNAJC7 Recombinant Antibody (4G6-G3) (CBMAB-D1321-YC)

Provided herein is a Mouse monoclonal antibody, which binds to DnaJ Heat Shock Protein Family (Hsp40) Member C7 (DNAJC7). The antibody can be used for immunoassay techniques, such as ELISA, IF, WB.
See all DNAJC7 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4G6-G3
Antibody Isotype
IgG2a, κ
Application
ELISA, IF, WB

Basic Information

Immunogen
DNAJC7 (AAH33772, 1 a.a. ~ 484 a.a) full-length recombinant protein with GST tag. The immunogen sequence: MAATEPELLD DQEAKREAET FKEQGNAYYA KKDYNEAYNY YTKAIDMCPK NASYYGNRAA TLMMLGRFRE ALGDAQQSVR LDDSFVRGHL REGKCHLSLG NAMAACRSFQ RALELDHKNA QAQQEFKNAN AVMEYEKIAE TDFEKRDFRK VVFCMDRALE FAPACHRFKI LKAECLAMLG RYPEAQSVAS DILRMDSTNA DALYVRGLCL YYEDCIEKAV QFFVQALRMA PDHEKACIAC RNAKALKAKK EDGNKAFKEG NYKLAYELYT EALGIDPNNI KTNAKLYCNR GTVNSKLRKL DDAIEDCTNA VKLDDTYIKA YLRRAQCYMD TEQYEEAVRD YEKVYQTEKT KEHKQLLKNA QLELKKSKRK DYYKILGVDK NASEDEIKKA YRKRALMHHP DRHSGASAEV QKEEEKKFKE VGEAFTILSD PKKKTRYDSG QDLDEEGMNM GDFDPNNIFK AFFGGPGGFS FEASGPGNFF FQFG
Specificity
Human
Antibody Isotype
IgG2a, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-484

Target

Full Name
DnaJ (Hsp40) homolog, subfamily C, member 7
Introduction
DNAJC7 belongs to the DNAJ heat shock protein 40 family of proteins that is characterized by two N-terminal tetratricopeptide repeat domains and a C-terminal DNAJ domain. This protein binds the chaperone proteins heat shock proteins 70 and 90 in an ATP-dependent manner and may function as a co-chaperone.
Entrez Gene ID
7266
UniProt ID
Q99615
Alternative Names
DnaJ Heat Shock Protein Family (Hsp40) Member C7; DnaJ (Hsp40) Homolog, Subfamily C, Member 7; Tetratricopeptide Repeat Protein 2; TPR Repeat Protein 2; TTC2; TPR2;
Function
Acts as co-chaperone regulating the molecular chaperones HSP70 and HSP90 in folding of steroid receptors, such as the glucocorticoid receptor and the progesterone receptor. Proposed to act as a recycling chaperone by facilitating the return of chaperone substrates to early stages of chaperoning if further folding is required. In vitro, induces ATP-independent dissociation of HSP90 but not of HSP70 from the chaperone-substrate complexes. Recruits NR1I3 to the cytoplasm (By similarity).
Biological Process
Chaperone cofactor-dependent protein refolding Source: UniProtKB
Protein folding Source: ProtInc
Regulation of cellular response to heat Source: Reactome
Cellular Location
Cytoplasm; Cytoskeleton; Nucleus. Colocalizes with NR1I3 to microtubules.

Dilliott, A. A., Andary, C. M., Stoltz, M., Petropavlovskiy, A. A., Farhan, S. M., & Duennwald, M. L. (2022). DnaJC7 in Amyotrophic Lateral Sclerosis. International Journal of Molecular Sciences, 23(8), 4076.

Tohnai, G., Nakamura, R., Atsuta, N., Nakatochi, M., Hayashi, N., Ito, D., ... & Japanese Consortium for Amyotrophic Lateral Sclerosis Research (JaCALS. (2022). Mutation screening of the DNAJC7 gene in Japanese patients with sporadic amyotrophic lateral sclerosis. Neurobiology of aging, 113, 131-136.

Hou, Z., Wydorski, P. M., Perez, V. A., Mendoza-Oliva, A., Ryder, B. D., Mirbaha, H., ... & Joachimiak, L. A. (2021). DnaJC7 binds natively folded structural elements in tau to inhibit amyloid formation. Nature communications, 12(1), 1-17.

He, J., Ma, X., Yu, W., Tang, L., Fu, J., Liu, X., ... & Fan, D. (2021). Validation of the pathogenic role of rare DNAJC7 variants in Chinese patients with amyotrophic lateral sclerosis. Neurobiology of Aging, 106, 314-e1.

Sun, X., Zhao, X., Liu, Q., Zhang, K., Liu, S., Wang, Z., ... & Zhang, X. (2021). Mutations of DNAJC7 are rare in Chinese amyotrophic lateral sclerosis patients. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 22(3-4), 312-315.

Jih, K. Y., Tsai, P. C., Tsai, Y. S., Liao, Y. C., & Lee, Y. C. (2020). Rapid progressive ALS in a patient with a DNAJC7 loss-of-function mutation. Neurology Genetics, 6(5).

Wang, M., Liu, Z., Yuan, Y., Ni, J., Li, W., Hu, Y., ... & Wang, J. (2020). A novel potentially pathogenic rare variant in the DNAJC7 gene identified in amyotrophic lateral sclerosis patients from Mainland China. Frontiers in Genetics, 821.

Farhan, S. M., Howrigan, D. P., Abbott, L. E., Klim, J. R., Topp, S. D., Byrnes, A. E., ... & Neale, B. M. (2020). Publisher Correction: Exome sequencing in amyotrophic lateral sclerosis implicates a novel gene, DNAJC7, encoding a heat-shock protein. Nature neuroscience, 23(2), 295-295.

Farhan, S. M., Howrigan, D. P., Abbott, L. E., Klim, J. R., Topp, S. D., Byrnes, A. E., ... & Neale, B. M. (2019). Exome sequencing in amyotrophic lateral sclerosis implicates a novel gene, DNAJC7, encoding a heat-shock protein. Nature neuroscience, 22(12), 1966-1974.

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For research use only. Not intended for any clinical use.

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