Mouse Anti-DNMBP Recombinant Antibody (3H7) (CBMAB-D1390-YC)

Name: Mouse Anti-DNMBP Recombinant Antibody (3H7)
SKU: CBMAB-D1390-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

3H7

Application

Immunogen

DNMBP (AAH41628, 491 a.a. ~ 590 a.a) partial recombinant protein with GST tag.

Specificity

Human

Antibody Isotype

IgG3, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Dynamin Binding Protein

Introduction

DNMBP is a protein belonging to the guanine nucleotide exchange factor family, and which regulates the configuration of cell junctions. It contains multiple binding sites for dynamin and thus links dynamin to actin regulatory proteins. Polymorphisms in this gene have been linked to Alzheimer's disease in some populations, though there are conflicting reports of such linkages in other populations.

Entrez Gene ID

23268

UniProt ID

Q6XZF7

Alternative Names

Dynamin Binding Protein; Scaffold Protein TUBA; Dynamin-Binding Protein; ARHGEF36; KIAA1010; TUBA;

Function

Plays a critical role as a guanine nucleotide exchange factor (GEF) for CDC42 in several intracellular processes associated with the actin and microtubule cytoskeleton. Regulates the structure of apical junctions through F-actin organization in epithelial cells (PubMed:19767742, PubMed:17015620).

Participates in the normal lumenogenesis of epithelial cell cysts by regulating spindle orientation (PubMed:20479467).

Plays a role in ciliogenesis (By similarity).

May play a role in membrane trafficking between the cell surface and the Golgi (By similarity).

Biological Process

Aging Source: Ensembl
Intracellular signal transduction Source: InterPro
Regulation of cell shape Source: UniProtKB
Regulation of small GTPase mediated signal transduction Source: Reactome

Cellular Location

Cytoskeleton; Cytoplasm; Golgi stack; Synapse; Cell junction. Localizes to the apical junction, colocalizes with TJP1.

Involvement in disease

Cataract 48 (CTRCT48):
A form of cataract, an opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function. CTRCT48 is an autosomal recessive form characterized by infantile or early-childhood onset.

DeLay, B. D., Baldwin, T. A., & Miller, R. K. (2019). Dynamin binding protein is required for Xenopus laevis kidney development. Frontiers in Physiology, 10, 143.

Ansar, M., Chung, H. L., Taylor, R. L., Nazir, A., Imtiaz, S., Sarwar, M. T., ... & Antonarakis, S. E. (2018). Bi-allelic loss-of-function variants in DNMBP cause infantile cataracts. The American Journal of Human Genetics, 103(4), 568-578.

Singh, P. (2017). Analysis of variants of Dnmbp, a Putative Modifier of Cecr2 and Neural Tube Defect Susceptibility Gene.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Mouse Anti-DNMBP Recombinant Antibody (3H7) (CAT#: V2LY-0425-LY709)

Antibody Pairs

DNMBP Matched Antibody Pair (350) (CAT#: APMAB-350LY)

Related Products

Mouse Anti-DNMBP Recombinant Antibody (3H7) (CAT#: V2LY-0425-LY709)

DNMBP Matched Antibody Pair (350) (CAT#: APMAB-350LY)

Mouse Anti-DNMBP Recombinant Antibody (1H2) (CAT#: CBMAB-D1392-YC)

Mouse Anti-DNMBP Recombinant Antibody (1H2) (CAT#: V2LY-0425-LY710)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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