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Mouse Anti-DNMBP Recombinant Antibody (3H7) (CBMAB-D1390-YC)

Provided herein is a Mouse monoclonal antibody, which binds to Dynamin Binding Protein (DNMBP). The antibody can be used for immunoassay techniques, such as WB.
See all DNMBP antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3H7
Antibody Isotype
IgG3, κ
Application
WB

Basic Information

Immunogen
DNMBP (AAH41628, 491 a.a. ~ 590 a.a) partial recombinant protein with GST tag.
Specificity
Human
Antibody Isotype
IgG3, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Dynamin Binding Protein
Introduction
DNMBP is a protein belonging to the guanine nucleotide exchange factor family, and which regulates the configuration of cell junctions. It contains multiple binding sites for dynamin and thus links dynamin to actin regulatory proteins. Polymorphisms in this gene have been linked to Alzheimer's disease in some populations, though there are conflicting reports of such linkages in other populations.
Entrez Gene ID
23268
UniProt ID
Q6XZF7
Alternative Names
Dynamin Binding Protein; Scaffold Protein TUBA; Dynamin-Binding Protein; ARHGEF36; KIAA1010; TUBA;
Function
Plays a critical role as a guanine nucleotide exchange factor (GEF) for CDC42 in several intracellular processes associated with the actin and microtubule cytoskeleton. Regulates the structure of apical junctions through F-actin organization in epithelial cells (PubMed:19767742, PubMed:17015620).

Participates in the normal lumenogenesis of epithelial cell cysts by regulating spindle orientation (PubMed:20479467).

Plays a role in ciliogenesis (By similarity).

May play a role in membrane trafficking between the cell surface and the Golgi (By similarity).
Biological Process
Aging Source: Ensembl
Intracellular signal transduction Source: InterPro
Regulation of cell shape Source: UniProtKB
Regulation of small GTPase mediated signal transduction Source: Reactome
Cellular Location
Cytoskeleton; Cytoplasm; Golgi stack; Synapse; Cell junction. Localizes to the apical junction, colocalizes with TJP1.
Involvement in disease
Cataract 48 (CTRCT48):
A form of cataract, an opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function. CTRCT48 is an autosomal recessive form characterized by infantile or early-childhood onset.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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