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Mouse Anti-DNMBP Recombinant Antibody (3H7) (V2LY-0425-LY709)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
3H7
Antibody Isotype
IgG3, κ
Application
ELISA, WB

Basic Information

Immunogen
DNMBP (aa491-590) partial recombinant protein.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG3, κ
Clonality
Monoclonal Antibody

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
None
Concentration
Batch dependent
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Dynamin Binding Protein
Entrez Gene ID
23268
UniProt ID
Q6XZF7
Function
Plays a critical role as a guanine nucleotide exchange factor (GEF) for CDC42 in several intracellular processes associated with the actin and microtubule cytoskeleton. Regulates the structure of apical junctions through F-actin organization in epithelial cells (PubMed:19767742, PubMed:17015620).

Participates in the normal lumenogenesis of epithelial cell cysts by regulating spindle orientation (PubMed:20479467).

Plays a role in ciliogenesis (By similarity).

May play a role in membrane trafficking between the cell surface and the Golgi (By similarity).
Biological Process
Aging Source: Ensembl
Intracellular signal transduction Source: InterPro
Regulation of cell shape Source: UniProtKB
Regulation of small GTPase mediated signal transduction Source: Reactome
Cellular Location
Cytoskeleton; Cytoplasm; Golgi stack; Synapse; Cell junction. Localizes to the apical junction, colocalizes with TJP1.
Involvement in disease
Cataract 48 (CTRCT48):
A form of cataract, an opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function. CTRCT48 is an autosomal recessive form characterized by infantile or early-childhood onset.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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