Mouse Anti-DPF2 Recombinant Antibody (226CT14.1.1.2) (CBMAB-D1544-YC)

Name: Mouse Anti-DPF2 Recombinant Antibody (226CT14.1.1.2)
SKU: CBMAB-D1544-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

226CT14.1.1.2

Application

Immunogen

DPF2 recombinant protein

Specificity

Human

Antibody Isotype

IgG3, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

D4, zinc and double PHD fingers family 2

Introduction

DPF2 is a member of the d4 domain family, characterized by a zinc finger-like structural motif. This protein functions as a transcription factor which is necessary for the apoptotic response following deprivation of survival factors. It likely serves a regulatory role in rapid hematopoietic cell growth and turnover. This gene is considered a candidate gene for multiple endocrine neoplasia type I, an inherited cancer syndrome involving multiple parathyroid, enteropancreatic, and pituitary tumors.

Entrez Gene ID

5977

UniProt ID

Q92785

Alternative Names

Double PHD Fingers 2; D4, Zinc And Double PHD Fingers Family 2; Apoptosis Response Zinc Finger Protein; BRG1-Associated Factor 45D; Protein Requiem; BAF45D; UBID4;

Function

Plays an active role in transcriptional regulation by binding modified histones H3 and H4 (PubMed:28533407, PubMed:27775714).

Is a negative regulator of myeloid differentiation of hematopoietic progenitor cells (PubMed:28533407).

Might also have a role in the development and maturation of lymphoid cells (By similarity).

Involved in the regulation of non-canonical NF-kappa-B pathway (PubMed:20460684).

Biological Process

Apoptotic process Source: ProtInc
Apoptotic signaling pathway Source: ProtInc
Chromatin organization Source: UniProtKB-KW
Negative regulation of myeloid progenitor cell differentiation Source: UniProtKB
Negative regulation of transcription, DNA-templated Source: GO_Central
Negative regulation of transcription by RNA polymerase II Source: ARUK-UCL
Nervous system development Source: GO_Central
Positive regulation of transcription by RNA polymerase II Source: GO_Central

Cellular Location

Cytoplasm; Nucleus

Involvement in disease

Coffin-Siris syndrome 7 (CSS7):
A form of Coffin-Siris syndrome, a congenital multiple malformation syndrome with broad phenotypic and genetic variability. Cardinal features are intellectual disability, coarse facial features, hypertrichosis, and hypoplastic or absent fifth digit nails or phalanges. Additional features include malformations of the cardiac, gastrointestinal, genitourinary, and/or central nervous systems. Sucking/feeding difficulties, poor growth, ophthalmologic abnormalities, hearing impairment, and spinal anomalies are common findings. Both autosomal dominant and autosomal recessive inheritance patterns have been reported. CSS7 inheritance is autosomal dominant.

Vasileiou, G., Vergarajauregui, S., Endele, S., Popp, B., Büttner, C., Ekici, A. B., ... & Reis, A. (2018). Mutations in the BAF-complex subunit DPF2 are associated with Coffin-Siris syndrome. The American Journal of Human Genetics, 102(3), 468-479.

Huber, F. M., Greenblatt, S. M., Davenport, A. M., Martinez, C., Xu, Y., Vu, L. P., ... & Hoelz, A. (2017). Histone-binding of DPF2 mediates its repressive role in myeloid differentiation. Proceedings of the National Academy of Sciences, 114(23), 6016-6021.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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