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Mouse Anti-DPF2 Recombinant Antibody (CBFYD-003) (CBMAB-D0003-FY)

This product is mouse antibody that recognizes DPF2. The antibody CBFYD-003 can be used for immunoassay techniques such as: ELISA, IF, IHC-P, WB.
See all DPF2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYD-003
Antibody Isotype
IgG2a
Application
ELISA, IF, IHC-P, WB

Basic Information

Immunogen
Recombinant protein, DPF2 partial recombinant protein with GST tag. MW of the GST tag alone is 26 kD.
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 56-155

Target

Full Name
D4, zinc and double PHD fingers family 2
Introduction
This gene is considered a candidate gene for multiple endocrine neoplasia type I, an inherited cancer syndrome involving multiple parathyroid, enteropancreatic, and pituitary tumors.
Entrez Gene ID
5977
UniProt ID
Q92785
Alternative Names
REQ; UBID4; ubi-d4
Function
Plays an active role in transcriptional regulation by binding modified histones H3 and H4 (PubMed:28533407, PubMed:27775714).

Is a negative regulator of myeloid differentiation of hematopoietic progenitor cells (PubMed:28533407).

Might also have a role in the development and maturation of lymphoid cells (By similarity).

Involved in the regulation of non-canonical NF-kappa-B pathway (PubMed:20460684).
Biological Process
Apoptotic process Source: ProtInc
Apoptotic signaling pathway Source: ProtInc
Chromatin organization Source: UniProtKB-KW
Negative regulation of myeloid progenitor cell differentiation Source: UniProtKB
Negative regulation of transcription, DNA-templated Source: GO_Central
Negative regulation of transcription by RNA polymerase II Source: ARUK-UCL
Nervous system development Source: GO_Central
Positive regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Cytoplasm; Nucleus
Involvement in disease
Coffin-Siris syndrome 7 (CSS7):
A form of Coffin-Siris syndrome, a congenital multiple malformation syndrome with broad phenotypic and genetic variability. Cardinal features are intellectual disability, coarse facial features, hypertrichosis, and hypoplastic or absent fifth digit nails or phalanges. Additional features include malformations of the cardiac, gastrointestinal, genitourinary, and/or central nervous systems. Sucking/feeding difficulties, poor growth, ophthalmologic abnormalities, hearing impairment, and spinal anomalies are common findings. Both autosomal dominant and autosomal recessive inheritance patterns have been reported. CSS7 inheritance is autosomal dominant.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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