Mouse Anti-DR1 Recombinant Antibody (D1665) (V2LY-0425-LY915)

Name: Mouse Anti-DR1 Recombinant Antibody (D1665)
SKU: V2LY-0425-LY915
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

D1665

Application

WB, IP, IF, ELISA

Immunogen

Full length of human DR1.

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal Antibody

Application Notes

Application	Note
ELISA	1:100-1:1,000
WB	1:100-1:1,000
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)	1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

Gelatin & PBS

Preservative

Sodium Azide

Concentration

0.2 mg/ml

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

DR1

Entrez Gene ID

Human	1810
Mouse	13486
Rat	289881

UniProt ID

Human	Q01658
Mouse	Q91WV0
Rat	Q5XI68

Function

The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.

Biological Process

Chromatin remodeling Source: GO_Central
Histone H3 acetylation Source: BHF-UCL
Negative regulation of transcription by RNA polymerase II Source: ARUK-UCL
Positive regulation of transcription by RNA polymerase II Source: GO_Central
RNA polymerase II preinitiation complex assembly Source: GO_Central

Cellular Location

Nucleus

PTM

Phosphorylation regulates its interaction with TBP. Not phosphorylated when bound to DRAP1.

Mamoor, S. (2021). DR1 is differentially expressed in brain metastatic human breast cancer.

Zhang, S., Li, J., Li, J., Yang, Y., Kang, X., Li, Y., ... & Hu, Y. (2018). Up-regulation of microRNA-203 in influenza A virus infection inhibits viral replication by targeting DR1. Scientific reports, 8(1), 1-15.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-DR1 Recombinant Antibody (D1664) (CAT#: CBMAB-D1664-YC)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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