Mouse Anti-DSCAM Recombinant Antibody (CBYCD-417) (V2LY-0425-LY959)

Name: Mouse Anti-DSCAM Recombinant Antibody (CBYCD-417)
SKU: V2LY-0425-LY959
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYCD-417

Application

WB, IHC

Immunogen

Chicken Dscam C-terminal region (aa1207-1527).

Host Species

Mouse

Specificity

Mouse, Chicken

Antibody Isotype

IgG1, κ

Clonality

Monoclonal Antibody

Application Notes

Application	Note
IHC	1:250-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

Trehalose & PBS

Preservative

None

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

DS Cell Adhesion Molecule

Entrez Gene ID

13508

UniProt ID

Q9ERC8

Research Area

Cell adhesion molecule that plays a role in neuronal self-avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Mediates within retinal amacrine and ganglion cell subtypes both isoneuronal self-avoidance for creating an orderly dendritic arborization and heteroneuronal self-avoidance to maintain the mosaic spacing between amacrine and ganglion cell bodies (PubMed:10925149).

Receptor for netrin required for axon guidance independently of and in collaboration with the receptor DCC. Might also collaborate with UNC5C in NTN1-mediated axon repulsion independently of DCC (By similarity).

In spinal cord development plays a role in guiding commissural axons projection and pathfinding across the ventral midline to reach the floor plate upon ligand binding (PubMed:18585357, PubMed:19196994).

Enhances netrin-induced phosphorylation of PAK1 and FYN (PubMed:15169762).

Mediates intracellular signaling by stimulating the activation of MAPK8 and MAP kinase p38 (PubMed:18585357, PubMed:19196994).

Adhesion molecule that promotes lamina-specific synaptic connections in the retina: expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions (By similarity).

Biological Process

Axon guidance Source: UniProtKB
Camera-type eye photoreceptor cell differentiation Source: UniProtKB
Cell adhesion Source: ProtInc
Dendrite morphogenesis Source: Ensembl
Dendrite self-avoidance Source: UniProtKB
Homophilic cell adhesion via plasma membrane adhesion molecules Source: UniProtKB
Locomotory behavior Source: Ensembl
Negative regulation of cell adhesion Source: UniProtKB
Nervous system development Source: ProtInc
Positive regulation of axon extension involved in axon guidance Source: UniProtKB
Positive regulation of phosphorylation Source: UniProtKB
Post-embryonic retina morphogenesis in camera-type eye Source: Ensembl
Retina layer formation Source: UniProtKB
Synapse assembly Source: UniProtKB

Cellular Location

Isoform Short: Secreted
Isoform Long: Cell membrane; Axon; Dendrite; Growth cone; Synapse. Localized in the soma, cell membrane, axon and growth cone of dissociated commissural axons.

Topology

Extracellular: 18-1595
Helical: 1596-1616
Cytoplasmic: 1617-2012

PTM

Phosphorylated at tyrosine residues. Phosphorylation is enhanced by NTN1.

Mitsogiannis, M. D., Pancho, A., Aerts, T., Sachse, S. M., Vanlaer, R., Noterdaeme, L., ... & Seuntjens, E. (2021). Subtle Roles of Down Syndrome Cell Adhesion Molecules in Embryonic Forebrain Development and Neuronal Migration. Frontiers in cell and developmental biology, 1859.

Tang, X. Y., Xu, L., Wang, J., Hong, Y., Wang, Y., Zhu, Q., ... & Liu, Y. (2021). DSCAM/PAK1 pathway suppression reverses neurogenesis deficits in iPSC-derived cerebral organoids from patients with Down syndrome. The Journal of clinical investigation, 131(12).

Chen, H., & Cai, K. (2020). DSCAM-AS1 mediates pro-hypertrophy role of GRK2 in cardiac hypertrophy aggravation via absorbing miR-188-5p. In Vitro Cellular & Developmental Biology-Animal, 56(4), 286-295.

Ng, T. H., Kumar, R., Apitanyasai, K., He, S. T., Chiu, S. P., & Wang, H. C. (2019). Selective expression of a “correct cloud” of Dscam in crayfish survivors after second exposure to the same pathogen. Fish & Shellfish Immunology, 92, 430-437.

Li, D., Wan, Z., Li, X., Duan, M., Yang, L., Ruan, Z., ... & Li, W. (2019). Alternatively spliced down syndrome cell adhesion molecule (Dscam) controls innate immunity in crab. Journal of Biological Chemistry, 294(44), 16440-16450.

Li, X. J., Yang, L., Li, D., Zhu, Y. T., Wang, Q., & Li, W. W. (2018). Pathogen-specific binding soluble down syndrome cell adhesion molecule (Dscam) regulates phagocytosis via membrane-bound Dscam in crab. Frontiers in Immunology, 9, 801.

Lowe, S. A., Hodge, J. J., & Usowicz, M. M. (2018). A third copy of the Down syndrome cell adhesion molecule (Dscam) causes synaptic and locomotor dysfunction in Drosophila. Neurobiology of Disease, 110, 93-101.

Stachowicz, K. (2018). The role of DSCAM in the regulation of synaptic plasticity: Possible involvement in neuropsychiatric disorders. Acta Neurobiol. Exp, 78(3), 210-219.

Montesinos, M. L. (2017). Local translation of the Down syndrome cell adhesion molecule (DSCAM) mRNA in the vertebrate central nervous system. Journal of Neurogenetics, 31(4), 223-230.

Jia, Y. L., Fu, Z. X., Zhang, B. H., & Jia, Y. J. (2017). Hippocampal overexpression of Down syndrome cell adhesion molecule in amyloid precursor protein transgenic mice. Brazilian Journal of Medical and Biological Research, 50.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Alternative Versions

Mouse Anti-DSCAM Recombinant Antibody (CBYCD-417) (CAT#: CBMAB-D1727-YC)

Related Products

Mouse Anti-DSCAM Recombinant Antibody (CBYCD-417) (CAT#: CBMAB-D1727-YC)

Mouse Anti-DSCAM Recombinant Antibody (CBYCD-416) (CAT#: V2LY-0425-LY958)

Mouse Anti-DSCAM Recombinant Antibody (CBYCD-416) (CAT#: CBMAB-D1724-YC)

Isotype control

For research use only. Not intended for any clinical use.

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