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Mouse Anti-DTNB Recombinant Antibody (3H8) (V2LY-0425-LY1033)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat, Monkey
Clone
3H8
Antibody Isotype
IgG2a
Application
FC, WB, IF

Basic Information

Immunogen
Full length human recombinant protein of human DTNB produced in HEK239T cell.
Host Species
Mouse
Specificity
Human, Mouse, Rat, Monkey
Antibody Isotype
IgG2a
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
IF(ICC)1:100
FC1:100

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
BSA & Glycerol & PBS
Preservative
Sodium Azide
Concentration
Batch dependent
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
dystrobrevin, beta
Entrez Gene ID
Human1838
Mouse13528
UniProt ID
HumanO60941
MouseO70585
Research Area
Scaffolding protein that assembles DMD and SNTA1 molecules to the basal membrane of kidney cells and liver sinusoids (By similarity).

May function as a repressor of the SYN1 promoter through the binding of repressor element-1 (RE-1), in turn regulates SYN1 expression and may be involved in cell proliferation regulation during the early phase of neural differentiation (PubMed:27223470).

May be required for proper maturation and function of a subset of inhibitory synapses (By similarity).
Biological Process
Neuron differentiation Source: UniProtKB
Synaptic signaling Source: GO_Central
Cellular Location
Nucleus; Cytoplasm; Basal cell membrane; Postsynaptic density; Dendrite; Postsynapse. Localized at inhibitory synapses on the dendrites of cerebellar Purkinje cells.
PTM
Phosphorylated by PKA. Phosphorylation at Thr-11 alters the interaction with KIF5A.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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