DTNB

This gene encodes dystrobrevin beta, a component of the dystrophin-associated protein complex (DPC). The DPC consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and dystrobrevin alpha and beta. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Dystrobrevin beta is thought to interact with syntrophin and the DP71 short form of dystrophin. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq]
Full Name
dystrobrevin, beta
Research Area
Scaffolding protein that assembles DMD and SNTA1 molecules to the basal membrane of kidney cells and liver sinusoids (By similarity).

May function as a repressor of the SYN1 promoter through the binding of repressor element-1 (RE-1), in turn regulates SYN1 expression and may be involved in cell proliferation regulation during the early phase of neural differentiation (PubMed:27223470).

May be required for proper maturation and function of a subset of inhibitory synapses (By similarity).
Biological Process
Neuron differentiation Source: UniProtKB
Synaptic signaling Source: GO_Central
Cellular Location
Nucleus; Cytoplasm; Basal cell membrane; Postsynaptic density; Dendrite; Postsynapse. Localized at inhibitory synapses on the dendrites of cerebellar Purkinje cells.
PTM
Phosphorylated by PKA. Phosphorylation at Thr-11 alters the interaction with KIF5A.
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Anti-DTNB antibodies

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Mouse Anti-DTNB Recombinant Antibody (3H8) (CBMAB-D1847-YC)

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Target: DTNB
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 3H8
Application*: F
Datasheet SDS

Mouse Anti-DTNB Recombinant Antibody (2E3) (CBMAB-D1842-YC)

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Target: DTNB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey, Mouse
Clone: 2E3
Application*: WB
Datasheet SDS

Mouse Anti-DTNB Recombinant Antibody (1D3) (CBMAB-D1841-YC)

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Target: DTNB
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1D3
Application*: E
Datasheet SDS

Mouse Anti-DTNB Recombinant Antibody (3H8) (V2LY-0425-LY1033)

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Target: DTNB
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat, Monkey
Clone: 3H8
Application*: F, WB, IF
Datasheet SDS

Mouse Anti-DTNB Recombinant Antibody (2E3) (V2LY-0425-LY1032)

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Target: DTNB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 2E3
Application*: IF, WB, IH
Datasheet SDS

Mouse Anti-DTNB Recombinant Antibody (1D3) (V2LY-0425-LY1031)

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Target: DTNB
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: 1D3
Application*: E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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