DTNB

This gene encodes dystrobrevin beta, a component of the dystrophin-associated protein complex (DPC). The DPC consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and dystrobrevin alpha and beta. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Dystrobrevin beta is thought to interact with syntrophin and the DP71 short form of dystrophin. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq]

dystrobrevin, beta

Scaffolding protein that assembles DMD and SNTA1 molecules to the basal membrane of kidney cells and liver sinusoids (By similarity).

May function as a repressor of the SYN1 promoter through the binding of repressor element-1 (RE-1), in turn regulates SYN1 expression and may be involved in cell proliferation regulation during the early phase of neural differentiation (PubMed:27223470).

May be required for proper maturation and function of a subset of inhibitory synapses (By similarity).

Neuron differentiation Source: UniProtKB
Synaptic signaling Source: GO_Central

Nucleus; Cytoplasm; Basal cell membrane; Postsynaptic density; Dendrite; Postsynapse. Localized at inhibitory synapses on the dendrites of cerebellar Purkinje cells.

Phosphorylated by PKA. Phosphorylation at Thr-11 alters the interaction with KIF5A.