Sign in or Register   Sign in or Register
  |  

Mouse Anti-USP17L2 Recombinant Antibody (3G12) (CBMAB-A2383-LY)

The product is antibody recognizes DUB3. The antibody 3G12 immunoassay techniques such as: WB, ELISA.
See all USP17L2 antibodies
Published Data
Fig.1 Immunohistochemistry analysis of Dub3 protein levels in ovarian tissues.
...View More
Fig.2 Dub3 affects H2A(X) monoubiquitination.
...View More

Summary

Host Animal
Mouse
Specificity
Human
Clone
3G12
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
DUB3 (NP_958804, 431 a.a. ~ 530 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Ubiquitin Specific Peptidase 17-Like Family Member 2
Introduction
DUB3 is a member of the ubiquitin processing protease (UBP) subfamily of deubiquitinating enzymes. See USP1 (MIM 603478) for background information.[supplied by OMIM
Entrez Gene ID
377630
UniProt ID
Q6R6M4
Function
Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Regulates cell proliferation by deubiquitinating and inhibiting RCE1 thereby controlling the small GTPases NRAS and HRAS localization and activation. In parallel, mediates deubiquitination of CDC25A, preventing CDC25A degradation by the proteasome during the G1/S and G2/M phases promoting cell-cycle progression. Also regulates cell proliferation and apoptosis through deubiquitination of SUDS3 a regulator of histone deacetylation. Through activation of the Rho family GTPases RAC1A, CDC42 and RHOA, regulates cell migration. Through the cleavage of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains of the cytoplasmic innate immune receptors RIGI and IFIH1 stimulates the cellular response to viral infection.
Biological Process
Biological Process apoptotic process Source:UniProtKB-KW
Biological Process CAAX-box protein processing Source:UniProtKB1 Publication
Biological Process cell cycle Source:UniProtKB-KW
Biological Process MAPK cascade Source:Reactome
Biological Process negative regulation of GTPase activity Source:UniProtKB1 Publication
Biological Process negative regulation of histone deacetylation Source:UniProtKB1 Publication
Biological Process negative regulation of protein processing Source:UniProtKB1 Publication
Biological Process negative regulation of protein targeting to membrane Source:UniProtKB1 Publication
Biological Process positive regulation of GTPase activity Source:UniProtKB1 Publication
Biological Process positive regulation of MDA-5 signaling pathway Source:UniProtKB1 Publication
Biological Process positive regulation of RIG-I signaling pathway Source:UniProtKB1 Publication
Biological Process protein deubiquitination Source:UniProtKB1 Publication
Biological Process protein K48-linked deubiquitination Source:UniProtKB2 Publications
Biological Process protein K63-linked deubiquitination Source:UniProtKB1 Publication
Biological Process regulation of apoptotic process Source:UniProtKB1 Publication
Biological Process regulation of cell migration Source:UniProtKB1 Publication
Biological Process regulation of cell population proliferation Source:UniProtKB1 Publication
Biological Process regulation of defense response to virus by host Source:UniProtKB1 Publication
Biological Process regulation of G2/MI transition of meiotic cell cycle Source:UniProtKB1 Publication
Biological Process regulation of ruffle assembly Source:UniProtKB1 Publication
Biological Process ubiquitin-dependent protein catabolic process Source:InterPro
Cellular Location
Nucleus
Endoplasmic reticulum
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-USP17L2 Recombinant Antibody (3G12)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare