Mouse Anti-DUSP14 Recombinant Antibody (4B5-E6) (CBMAB-D1884-YC)

Name: Mouse Anti-DUSP14 Recombinant Antibody (4B5-E6)
SKU: CBMAB-D1884-YC
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

4B5-E6

Antibody Isotype

IgG2a, κ

Application

ELISA, IF, WB

Basic Information

Immunogen

The immunogen sequence: MSSRGHSTLP RTLMAPRMIS EGDIGGIAQI TSSLFLGRGS VASNRHLLQA RGITCIVNAT IEIPNFNWPQ FEYVKVPLAD MPHAPIGLYF DTVADKIHSV SRKHGATLVH CAAGVSRSAT LCIAYLMKFH NVCLLEAYNW VKARRPVIRP NVGFWRQLID YERQLFGKST VKMVQTPYGI VPDVYEKESR HLMPYWGI

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 1-198

Target

Full Name

dual specificity phosphatase 14

Introduction

Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP14 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs.

Entrez Gene ID

11072

UniProt ID

O95147

Alternative Names

Dual Specificity Phosphatase 14; Mitogen-Activated Protein Kinase Phosphatase 6; MKP-1-Like Protein Tyrosine Phosphatase; MAP Kinase Phosphatase 6; MKP-6; MKP-L;

Research Area

Involved in the inactivation of MAP kinases. Dephosphorylates ERK, JNK and p38 MAP-kinases.

More Infomation

References

Xu, J., Ma, L., & Fu, P. (2021). Eriocitrin attenuates ischemia reperfusion-induced oxidative stress and inflammation in rats with acute kidney injury by regulating the dual-specificity phosphatase 14 (DUSP14)-mediated Nrf2 and nuclear factor-κB (NF-κB) pathways. Annals of Translational Medicine, 9(4).

Kumar, V., Ali Shariati, M., Mesentier-Louro, L., Jinsook Oh, A., Russano, K., Goldberg, J. L., & Liao, Y. J. (2021). Dual Specific Phosphatase 14 Deletion Rescues Retinal Ganglion Cells and Optic Nerve Axons after Experimental Anterior Ischemic Optic Neuropathy. Current Eye Research, 46(5), 710-718.

Zhao, Z., Yang, J., Zhang, L., & Zhou, Y. (2021). Enhancement of DUSP14 (dual specificity phosphatase 14) limits osteoarthritis progression by alleviating chondrocyte injury, inflammation and metabolic homeostasis. Bioengineered, 12(1), 7495-7507.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Alternative Versions

Mouse Anti-DUSP14 Recombinant Antibody (4B5-E6)

Related Products

Mouse Anti-DUSP14 Recombinant Antibody (4B5-E6)

Mouse Anti-DUSP14 Recombinant Antibody (4F6)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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