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Mouse Anti-DUSP27 Recombinant Antibody (AF16B7) (CBMAB-D1892-YC)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
AF16B7
Antibody Isotype
IgM, κ
Application
WB, IP, IF, ELISA

Basic Information

Immunogen
Amino acids 60-86 within an internal region of human DUSP27.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgM, κ
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
ELISA1:100-1:1,000
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Gelatin & PBS
Preservative
Sodium Azide
Concentration
0.2 mg/ml
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Dual Specificity Phosphatase 27, Atypical
Introduction
DUSP27 (Dual Specificity Phosphatase 27, Atypical) is a protein coding gene. It has proved that the protein has phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. And a paralog is DUPD1.
Entrez Gene ID
92235
UniProt ID
Q5VZP5
Alternative Names
Dual Specificity Phosphatase 27, Atypical; Dual Specificity Phosphatase 27 (Putative);
Research Area
Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues within the same substrate, with a preference for phosphotyrosine as a substrate (PubMed:17498703).

Involved in the modulation of intracellular signaling cascades. In skeletal muscle regulates systemic glucose homeostasis by activating, AMPK, an energy sensor protein kinase (By similarity).

Affects MAP kinase signaling though modulation of the MAPK1/2 cascade in skeletal muscle promoting muscle cell differentiation, development and atrophy (By similarity).
Biological Process
Glucose homeostasis Source: Ensembl
Muscle cell differentiation Source: UniProtKB
Negative regulation of ERK1 and ERK2 cascade Source: UniProtKB
Protein dephosphorylation Source: UniProtKB
Cellular Location
Nucleus; Cytoplasm
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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