Mouse Anti-DVL2 Recombinant Antibody (2D11) (CBMAB-D1930-YC)

Name: Mouse Anti-DVL2 Recombinant Antibody (2D11)
SKU: CBMAB-D1930-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

2D11

Application

Immunogen

E. coli-derived recombinant human Dishevelled-2 (Leu78-Thr250).

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

Trehalose & PBS

Preservative

None

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Dishevelled Segment Polarity Protein 2

Introduction

DVL2 belongs to the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans.

Entrez Gene ID

1856

UniProt ID

O14641

Alternative Names

Dishevelled Segment Polarity Protein 2; Dishevelled 2 (Homologous To Drosophila Dsh); Dishevelled, Dsh Homolog 2 (Drosophila); DSH Homolog 2; Dishevelled-2;

Research Area

Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling.

Biological Process

Canonical Wnt signaling pathway Source: BHF-UCL
Canonical Wnt signaling pathway involved in regulation of cell proliferation Source: BHF-UCL
Cellular protein localization Source: Ensembl
Cochlea morphogenesis Source: Ensembl
Convergent extension involved in neural plate elongation Source: Ensembl
Heart development Source: BHF-UCLIntracellular signal transduction Source: InterPro
Neural tube closure Source: BHF-UCL
Non-canonical Wnt signaling pathway Source: BHF-UCL
Outflow tract morphogenesis Source: BHF-UCL
Planar cell polarity pathway involved in neural tube closure Source: GO_Central
Positive regulation of DNA-binding transcription factor activity Source: BHF-UCL
Positive regulation of GTPase activity Source: Ensembl
Positive regulation of JUN kinase activity Source: BHF-UCL
Positive regulation of neuron projection arborization Source: ARUK-UCL
Positive regulation of protein phosphorylation Source: BHF-UCL
Positive regulation of protein tyrosine kinase activity Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Regulation of transcription, DNA-templated Source: UniProtKB
Segment specification Source: BHF-UCL
Wnt signaling pathway, planar cell polarity pathway Source: BHF-UCL

Cellular Location

Nucleus; Cytosol; Cell membrane; Cytoplasmic vesicle. Localizes at the cell membrane upon interaction with frizzled family members and promotes their internalization. Localizes to cytoplasmic puncta (By similarity). Interaction with FOXK1 and FOXK2 induces nuclear translocation (PubMed:25805136).

PTM

Phosphorylated by CSNK1D (PubMed:21422228, PubMed:9192851). WNT3A induces DVL2 phosphorylation by CSNK1E and MARK kinases (PubMed:25805136).

Zhao, D., Zhong, G., Li, J., Pan, J., Zhao, Y., Song, H., ... & Ling, S. (2021). Targeting E3 ubiquitin ligase WWP1 prevents cardiac hypertrophy through destabilizing DVL2 via inhibition of K27-linked ubiquitination. Circulation, 144(9), 694-711.

Sremac, M., Paic, F., Ravic, K. G., Serman, L., Dujmovic, A. P., Brcic, I., ... & Martic, T. N. (2021). Aberrant expression of SFRP1, SFRP3, DVL2 and DVL3 Wnt signaling pathway components in diffuse gastric carcinoma. Oncology Letters, 22(6), 1-19.

Esaki, N., Enomoto, A., Takagishi, M., Mizutani, Y., Iida, T., Ushida, K., ... & Takahashi, M. (2020). The Daple-CK1ε complex regulates Dvl2 phosphorylation and canonical Wnt signaling. Biochemical and Biophysical Research Communications, 532(3), 406-413.

Yu, F., Dong, P., Mao, Y., Zhao, B., Huang, Z., & Zheng, J. (2019). Loss of lncRNA-SNHG7 promotes the suppression of hepatic stellate cell activation via miR-378a-3p and DVL2. Molecular Therapy-Nucleic Acids, 17, 235-244.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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