DVL2

This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans. [provided by RefSeq, Jul 2008]

Full Name

Dishevelled Segment Polarity Protein 2

Research Area

Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling.

Biological Process

Canonical Wnt signaling pathway Source: BHF-UCL
Canonical Wnt signaling pathway involved in regulation of cell proliferation Source: BHF-UCL
Cellular protein localization Source: Ensembl
Cochlea morphogenesis Source: Ensembl
Convergent extension involved in neural plate elongation Source: Ensembl
Heart development Source: BHF-UCLIntracellular signal transduction Source: InterPro
Neural tube closure Source: BHF-UCL
Non-canonical Wnt signaling pathway Source: BHF-UCL
Outflow tract morphogenesis Source: BHF-UCL
Planar cell polarity pathway involved in neural tube closure Source: GO_Central
Positive regulation of DNA-binding transcription factor activity Source: BHF-UCL
Positive regulation of GTPase activity Source: Ensembl
Positive regulation of JUN kinase activity Source: BHF-UCL
Positive regulation of neuron projection arborization Source: ARUK-UCL
Positive regulation of protein phosphorylation Source: BHF-UCL
Positive regulation of protein tyrosine kinase activity Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Regulation of transcription, DNA-templated Source: UniProtKB
Segment specification Source: BHF-UCL
Wnt signaling pathway, planar cell polarity pathway Source: BHF-UCL

Cellular Location

Nucleus; Cytosol; Cell membrane; Cytoplasmic vesicle. Localizes at the cell membrane upon interaction with frizzled family members and promotes their internalization. Localizes to cytoplasmic puncta (By similarity). Interaction with FOXK1 and FOXK2 induces nuclear translocation (PubMed:25805136).

PTM

Phosphorylated by CSNK1D (PubMed:21422228, PubMed:9192851). WNT3A induces DVL2 phosphorylation by CSNK1E and MARK kinases (PubMed:25805136).