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Rat Anti-EDAR Recombinant Antibody (CBFYE-0428) (CBMAB-E0746-FY)


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Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBFYE-0428
Antibody Isotype
IgG2
Application
WB

Basic Information

Immunogen
Recombinant protein corresponding to mouse EDAR
Specificity
Mouse
Antibody Isotype
IgG2
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ectodysplasin A receptor
Introduction
This gene encodes a member of the tumor necrosis factor receptor family. The encoded transmembrane protein is a receptor for the soluble ligand ectodysplasin A, and can activate the nuclear factor-kappaB, JNK, and caspase-independent cell death pathways. It is required for the development of hair, teeth, and other ectodermal derivatives. Mutations in this gene result in autosomal dominant and recessive forms of hypohidrotic ectodermal dysplasia.
Entrez Gene ID
13608
UniProt ID
Q9R187
Alternative Names
dl; ED3; ED5; ED1R; EDA3; EDA-A1R
Research Area
Receptor for EDA isoform A1, but not for EDA isoform A2. Mediates the activation of NF-kappa-B and JNK. May promote caspase-independent cell death.
Biological Process
Apoptotic process Source: UniProtKB-KW
Cell differentiation Source: UniProtKB-KW
Epidermis development Source: HGNC-UCL
Hair follicle development Source: Ensembl
Odontogenesis of dentin-containing tooth Source: Ensembl
Pigmentation Source: Ensembl
Positive regulation of gene expression Source: Ensembl
Positive regulation of I-kappaB kinase/NF-kappaB signaling Source: GO_Central
Positive regulation of JNK cascade Source: GO_Central
Positive regulation of NIK/NF-kappaB signaling Source: Ensembl
Salivary gland cavitation Source: Ensembl
Cellular Location
Membrane
Involvement in disease
Ectodermal dysplasia 10A, hypohidrotic/hair/nail type, autosomal dominant (ECTD10A):
A form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. It is an autosomal dominant condition characterized by hypotrichosis, abnormal or missing teeth, and hypohidrosis due to the absence of sweat glands.
Ectodermal dysplasia 10B, hypohidrotic/hair/tooth type, autosomal recessive (ECTD10B):
A disorder due to abnormal development of two or more ectodermal structures, and characterized by sparse hair (atrichosis or hypotrichosis), abnormal or missing teeth and the inability to sweat due to the absence of sweat glands.
Topology
Extracellular: 27-187
Helical: 188-208
Cytoplasmic: 209-448
More Infomation

Laurentino, T. G., Boileau, N., Ronco, F., & Berner, D. (2022). The ectodysplasin-A receptor is a candidate gene for lateral plate number variation in stickleback fish. G3, 12(6), jkac077.

Ahmed, H. A., El-Kamah, G. Y., Rabie, E., Mostafa, M. I., Abouzaid, M. R., Hassib, N. F., ... & Sayed, I. S. (2021). Gene Mutations of the Three Ectodysplasin Pathway Key Players (EDA, EDAR, and EDARADD) Account for More than 60% of Egyptian Ectodermal Dysplasia: A Report of Seven Novel Mutations. Genes, 12(9), 1389.

Wang, B., Liang, Y., Chai, X., Chen, S., Ye, Z., Li, R., ... & Zeng, J. (2020). Ectodysplasin A receptor (EDAR) promotes colorectal cancer cell proliferation via regulation of the Wnt/β-catenin signaling pathway. Experimental Cell Research, 395(1), 112170.

Vial, J., Royet, A., Cassier, P., Tortereau, A., Dinvaut, S., Maillet, D., ... & Castets, M. (2019). The Ectodysplasin receptor EDAR acts as a tumor suppressor in melanoma by conditionally inducing cell death. Cell Death & Differentiation, 26(3), 443-454.

Wohlfart, S., & Schneider, H. (2019). Variants of the ectodysplasin A1 receptor gene underlying homozygous cases of autosomal recessive hypohidrotic ectodermal dysplasia. Clinical Genetics, 95(3), 427-432.

Zheng, X. D., Yang, Q. F., Xu, Z. Y., & Yang, D. Q. (2019). Expression patterns of ectodysplasin and ectodysplasin receptor during early dental development in zebrafish. Hua xi kou Qiang yi xue za zhi= Huaxi Kouqiang Yixue Zazhi= West China Journal of Stomatology, 37(4), 355-360.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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