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Mouse Anti-EDC4 Recombinant Antibody (2E2) (CBMAB-1531-CN)

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Datasheet
SDS
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal
Mouse
Clone
2E2
Application
ELISA, IF, IHC-P
Immunogen
EDC4 (NP_055144.3, aa. 1302-1401) partial recombinant protein with GST tag.
Specificity
Human
Antibody Isotype
IgG2a
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
1x PBS,  pH 7.4
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
enhancer of mRNA decapping 4
Introduction
In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2.
Entrez Gene ID
23644
UniProt ID
Q6P2E9
Alternative Names
GE1; Ge-1; RCD8; HEDL5; HEDLS; RCD-8
Research Area
In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro).
Biological Process
Deadenylation-independent decapping of nuclear-transcribed mRNA Source: GO_Central
Cellular Location
Nucleus; P-body

Wu, X., Zhong, Y., Chen, Q., Zhang, X., & Zhang, H. (2020). Enhancer of mRNA Decapping protein 4 (EDC4) interacts with replication protein a (RPA) and contributes to Cisplatin resistance in cervical Cancer by alleviating DNA damage. Hereditas, 157(1), 1-8.

Brothers, W. R., Hebert, S., Kleinman, C. L., & Fabian, M. R. (2020). A non-canonical role for the EDC4 decapping factor in regulating MARF1-mediated mRNA decay. Elife, 9, e54995.

Becker, H., Greve, G., Kataoka, K., Mallm, J. P., Duque-Afonso, J., Ma, T., ... & Lübbert, M. (2019). Identification of enhancer of mRNA decapping 4 as a novel fusion partner of MLL in acute myeloid leukemia. Blood advances, 3(5), 761.

Hernández, G., Ramírez, M. J., Minguillón, J., Quiles, P., Ruiz de Garibay, G., Aza-Carmona, M., ... & Surrallés, J. (2018). Decapping protein EDC4 regulates DNA repair and phenocopies BRCA1. Nature communications, 9(1), 1-11.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-EDC4 Recombinant Antibody (CBFYE-0433) (CAT#: V2LY-0425-LY1392)

Mouse Anti-EDC4 Recombinant Antibody (1531) (CAT#: V2LY-0425-LY1391)

Mouse Anti-EDC4 Recombinant Antibody (CBFYE-0433) (CAT#: CBMAB-E0753-FY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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