Mouse Anti-EDC4 Recombinant Antibody (CBFYE-0433) (CBMAB-E0753-FY)

Name: Mouse Anti-EDC4 Recombinant Antibody (CBFYE-0433)
SKU: CBMAB-E0753-FY
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBFYE-0433

Antibody Isotype

IgG2a, κ

Application

ELISA, IHC-P

Basic Information

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

enhancer of mRNA decapping 4

Introduction

The EDC4 scaffold, which may serve to couple DCP2 activation by DCP1 with 5′-to-3′ mRNA degradation by XRN1 in human cells.

Entrez Gene ID

23644

UniProt ID

Q6P2E9

Alternative Names

GE1; Ge-1; RCD8; HEDL5; HEDLS; RCD-8

Research Area

In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro).

Biological Process

Deadenylation-independent decapping of nuclear-transcribed mRNA Source: GO_Central

Cellular Location

Nucleus; P-body

More Infomation

References

Wu, X., Zhong, Y., Chen, Q., Zhang, X., & Zhang, H. (2020). Enhancer of mRNA Decapping protein 4 (EDC4) interacts with replication protein a (RPA) and contributes to Cisplatin resistance in cervical Cancer by alleviating DNA damage. Hereditas, 157(1), 1-8.

Brothers, W. R., Hebert, S., Kleinman, C. L., & Fabian, M. R. (2020). A non-canonical role for the EDC4 decapping factor in regulating MARF1-mediated mRNA decay. Elife, 9, e54995.

Becker, H., Greve, G., Kataoka, K., Mallm, J. P., Duque-Afonso, J., Ma, T., ... & Lübbert, M. (2019). Identification of enhancer of mRNA decapping 4 as a novel fusion partner of MLL in acute myeloid leukemia. Blood advances, 3(5), 761.

Hernández, G., Ramírez, M. J., Minguillón, J., Quiles, P., Ruiz de Garibay, G., Aza-Carmona, M., ... & Surrallés, J. (2018). Decapping protein EDC4 regulates DNA repair and phenocopies BRCA1. Nature communications, 9(1), 1-11.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

Mouse Anti-EDC4 Recombinant Antibody (2E2)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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