Mouse Anti-EDN1 Recombinant Antibody (3D6) (CBMAB-A2453-LY)

Mouse

Human

3D6

IgG2a, κ

WB, ELISA

EDN1 (AAH09720, 113 a.a. ~ 212 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Human

IgG2a, κ

Monoclonal

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Liquid

> 95% Purity determined by SDS-PAGE.

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Endothelin 1

ET1; HDLCQ7

Endothelins are endothelium-derived vasoconstrictor peptides (By similarity).

Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (PubMed:19086031).

Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: Ensembl
Artery smooth muscle contraction Source: BHF-UCL
Body fluid secretion Source: Ensembl
Branching involved in blood vessel morphogenesis Source: Ensembl
Calcium-mediated signaling Source: BHF-UCL
Cartilage development Source: Ensembl
Cell-cell signaling Source: BHF-UCL
Cell surface receptor signaling pathway Source: BHF-UCL
Cellular calcium ion homeostasis Source: GO_Central
Cellular response to calcium ion Source: Ensembl
Cellular response to drug Source: Ensembl
Cellular response to fatty acid Source: Ensembl
Cellular response to glucocorticoid stimulus Source: Ensembl
Cellular response to hypoxia Source: Ensembl
Cellular response to interferon-gamma Source: Ensembl
Cellular response to interleukin-1 Source: Ensembl
Cellular response to mineralocorticoid stimulus Source: Ensembl
Cellular response to peptide hormone stimulus Source: Ensembl
Cellular response to transforming growth factor beta stimulus Source: Ensembl
Cellular response to tumor necrosis factor Source: Ensembl
Dorsal/ventral pattern formation Source: Ensembl
Endothelin receptor signaling pathway Source: UniProtKB
Epithelial fluid transport Source: Ensembl
G protein-coupled receptor signaling pathway Source: BHF-UCL
Heart development Source: Ensembl
Histamine secretion Source: Ensembl
Inositol phosphate-mediated signaling Source: BHF-UCL
In utero embryonic development Source: Ensembl
Leukocyte activation Source: BHF-UCL
Maternal process involved in parturition Source: Ensembl
Membrane depolarization Source: Ensembl
Middle ear morphogenesis Source: Ensembl
Multicellular organism aging Source: Ensembl
Negative regulation of blood coagulation Source: BHF-UCL
Negative regulation of cellular protein metabolic process Source: BHF-UCL
Negative regulation of gene expression Source: Ensembl
Negative regulation of hormone secretion Source: Ensembl
Negative regulation of nitric-oxide synthase biosynthetic process Source: BHF-UCL
Negative regulation of smooth muscle cell apoptotic process Source: Ensembl
Negative regulation of transcription by RNA polymerase II Source: BHF-UCL
Neural crest cell development Source: Ensembl
Nitric oxide transport Source: BHF-UCL
Peptide hormone secretion Source: BHF-UCL
Phosphatidylinositol 3-kinase signaling Source: BHF-UCL
Phospholipase D-activating G protein-coupled receptor signaling pathway Source: Ensembl
Positive regulation of cardiac muscle hypertrophy Source: BHF-UCL
Positive regulation of cell growth involved in cardiac muscle cell development Source: BHF-UCL
Positive regulation of cell migration Source: BHF-UCL
Positive regulation of cell population proliferation Source: BHF-UCL
Positive regulation of cell size Source: BHF-UCL
Positive regulation of chemokine-mediated signaling pathway Source: BHF-UCL
Positive regulation of cytosolic calcium ion concentration Source: BHF-UCL
Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling Pathway Source: Ensembl
Positive regulation of DNA-binding transcription factor activity Source: BHF-UCL
Positive regulation of endothelial cell migration Source: BHF-UCL
Positive regulation of heart rate Source: BHF-UCL
Positive regulation of hormone secretion Source: BHF-UCL
Positive regulation of JUN kinase activity Source: BHF-UCL
Positive regulation of MAP kinase activity Source: BHF-UCL
Positive regulation of mitotic nuclear division Source: BHF-UCL
Positive regulation of neutrophil chemotaxis Source: Ensembl
Positive regulation of NIK/NF-kappaB signaling Source: Ensembl
Positive regulation of nitric oxide biosynthetic process Source: BHF-UCL
Positive regulation of odontogenesis Source: Ensembl
Positive regulation of prostaglandin-endoperoxide synthase activity Source: BHF-UCL
Positive regulation of prostaglandin secretion Source: Ensembl
Positive regulation of renal sodium excretion Source: Ensembl
Positive regulation of sarcomere organization Source: BHF-UCL
Positive regulation of signaling receptor activity Source: BHF-UCL
Positive regulation of smooth muscle cell proliferation Source: BHF-UCL
Positive regulation of smooth muscle contraction Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Positive regulation of urine volume Source: Ensembl
Positive regulation of vascular associated smooth muscle cell proliferation Source: Ensembl
Prostaglandin biosynthetic process Source: BHF-UCL
Protein kinase C-activating G protein-coupled receptor signaling pathway Source: Ensembl
Protein kinase C deactivation Source: BHF-UCL
Regulation of glucose transmembrane transport Source: Ensembl
Regulation of pH Source: Ensembl
Regulation of sensory perception of pain Source: Ensembl
Regulation of systemic arterial blood pressure by endothelin Source: BHF-UCL
Regulation of vasoconstriction Source: InterPro
Respiratory gaseous exchange by respiratory system Source: Ensembl
Response to activity Source: Ensembl
Response to amino acid Source: Ensembl
Response to dexamethasone Source: Ensembl
Response to leptin Source: Ensembl
Response to lipopolysaccharide Source: Ensembl
Response to muscle stretch Source: Ensembl
Response to nicotine Source: Ensembl
Response to ozone Source: Ensembl
Response to prostaglandin F Source: Ensembl
Response to salt Source: Ensembl
Response to testosterone Source: Ensembl
Rhythmic excitation Source: Ensembl
Sensory perception of pain Source: Ensembl
Superoxide anion generation Source: Ensembl
Vasoconstriction Source: BHF-UCL
Vein smooth muscle contraction Source: BHF-UCL

Secreted

Question mark ears, isolated (QME):
An auricular abnormality characterized by a cleft between the lobule and the lower part of the helix, sometimes accompanied by a prominent or deficient upper part of the helix, shallow skin dimple on the posterior surface of the ear, or transposition of the ear lobe/antitragus.
Auriculocondylar syndrome 3 (ARCND3):
A craniofacial malformation syndrome characterized by variable mandibular anomalies, including mild to severe micrognathia, temporomandibular joint ankylosis, cleft palate, and a characteristic ear malformation that consists of separation of the lobule from the external ear, giving the appearance of a question mark (question-mark ear). Other frequently described features include prominent cheeks, cupped and posteriorly rotated ears, preauricular tags, and microstomia.