Mouse Anti-EFHD1 (AA 168-238) Recombinant Antibody (CBFYE-0036) (CBMAB-E0068-FY)

Name: Mouse Anti-EFHD1 (AA 168-238) Recombinant Antibody (CBFYE-0036)
SKU: CBMAB-E0068-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYE-0036

Application

ELISA, WB

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 168-238

More Infomation

Target

Full Name

EF-Hand Domain Family Member D1

Introduction

This gene encodes a member of the EF-hand super family of calcium binding proteins, which are involved in a variety of cellular processes including mitosis, synaptic transmission, and cytoskeletal rearrangement. The protein encoded by this gene is composed of an N-terminal disordered region, proline-rich elements, two EF-hands, and a C-terminal coiled-coil domain. This protein has been shown to associate with the mitochondrial inner membrane, and in HeLa cells, acts as a novel mitochondrial calcium ion sensor for mitochondrial flash activation. Alternative splicing results in multiple transcript variants.

Entrez Gene ID

80303

UniProt ID

Q9BUP0

Alternative Names

EF-Hand Domain Family Member D1; Swiprosin-2; EF-Hand Domain-Containing Protein 1; SWS2; EF-Hand Domain-Containing Protein D1; EF Hand Domain Containing 1; MSTP133; MST133; PP3051

Research Area

Acts as a calcium sensor for mitochondrial flash (mitoflash) activation, an event characterized by stochastic bursts of superoxide production (PubMed:26975899).

May play a role in neuronal differentiation (By similarity).

Biological Process

Neuron projection development Source: Ensembl
Regulation of cellular hyperosmotic salinity response Source: UniProtKB

Cellular Location

Mitochondrion inner membrane

Eberhardt, D. R., Lee, S. H., Yin, X., Balynas, A. M., Rekate, E. C., Kraiss, J. N., ... & Chaudhuri, D. (2022). EFHD1 ablation inhibits cardiac mitoflash activation and protects cardiomyocytes from ischemia. Journal of Molecular and Cellular Cardiology, 167, 1-14.

Eberhardt, D. R., Lee, S. H., Yin, X., Balynas, A. M., Rekate, E., Kraiss, J. N., ... & Chaudhuri, D. (2021). EFHD1 ablation reduces cardiac mitoflash activation and protects cardiomyocytes from ischemia. bioRxiv.

Eberhardt, D. R., Yin, X., Balynas, A., Lee, S., Walsh, M., Funai, K., & Chaudhuri, D. (2021, September). Abstract P339: Examining Cardiac Phenotypes Of EF Hand Containing Domain 1 Protein (EFHD1) Knockout Mice. In Circulation Research (Vol. 129, No. Suppl_1, pp. AP339-AP339). Hagerstown, MD: Lippincott Williams & Wilkins.

Mun, S. A., Park, J., Park, K. R., Lee, Y., Kang, J. Y., Park, T., ... & Eom, S. H. (2021). Structural and biochemical characterization of EFhd1/Swiprosin-2, an actin-binding protein in mitochondria. Frontiers in cell and developmental biology, 8, 628222.

Ulisse, V., Dey, S., Rothbard, D. E., Zeevi, E., Gokhman, I., Dadosh, T., ... & Yaron, A. (2020). Regulation of axonal morphogenesis by the mitochondrial protein Efhd1. Life science alliance, 3(7).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Mouse Anti-EFHD1 Recombinant Antibody (CBFYE-0036) (CAT#: V2LY-0425-LY1491)

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Isotype control

For research use only. Not intended for any clinical use.

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