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Mouse Anti-EFNA5 Recombinant Antibody (1A2) (V2LY-0425-LY1520)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
1A2
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
Amino acid 114-203 of human ephrin-A5.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal Antibody

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
None
Concentration
Batch dependent
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Ephrin A5
Entrez Gene ID
Human1946
Mouse13640
Rat116683
UniProt ID
HumanP52803
MouseO08543
RatP97605
Research Area
Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the EPHA3 receptor to regulate cell-cell adhesion and cytoskeletal organization. With the receptor EPHA2 may regulate lens fiber cells shape and interactions and be important for lens transparency maintenance. May function actively to stimulate axon fasciculation. The interaction of EFNA5 with EPHA5 also mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion. Cognate/functional ligand for EPHA7, their interaction regulates brain development modulating cell-cell adhesion and repulsion.
Biological Process
Axon guidance Source: GO_Central
Ephrin receptor signaling pathway Source: UniProtKB
Negative regulation of substrate adhesion-dependent cell spreading Source: MGI
Nervous system development Source: ProtInc
Positive regulation of peptidyl-tyrosine phosphorylation Source: UniProtKB
Positive regulation of protein phosphorylation Source: BHF-UCL
Regulation of actin cytoskeleton organization Source: UniProtKB
Regulation of cell-cell adhesion Source: UniProtKB
Regulation of cell morphogenesis Source: MGI
Regulation of focal adhesion assembly Source: UniProtKB
Regulation of GTPase activity Source: UniProtKB
Regulation of insulin secretion involved in cellular response to glucose stimulus Source: UniProtKB
Regulation of microtubule cytoskeleton organization Source: UniProtKB
Cellular Location
Cell membrane; Caveola. Compartmentalized in discrete caveolae-like membrane microdomains.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

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