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Mouse Anti-EHBP1 Recombinant Antibody (A-8) (CBMAB-E1012-FY)

This product is mouse antibody that recognizes EHBP1. The antibody A-8 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all EHBP1 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Human
Clone
A-8
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Mouse, Rat, Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.2 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
EH Domain Binding Protein 1
Introduction
This gene encodes an Eps15 homology domain binding protein. The encoded protein may play a role in endocytic trafficking. A single nucleotide polymorphism in this gene is associated with an aggressive form of prostate cancer. Alternate splicing results in multiple transcript variants.
Entrez Gene ID
Human23301
Mouse216565
Rat305556
UniProt ID
HumanQ8NDI1
MouseQ69ZW3
RatF1LVX2
Alternative Names
EH Domain Binding Protein 1; NACSIN; Testis Tissue Sperm-Binding Protein Li 50e; EH Domain-Binding Protein 1; NPF Calponin-Like Protein; KIAA0903; HPC12
Research Area
May play a role in actin reorganization. Links clathrin-mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking (PubMed:14676205, PubMed:27552051).

Required for perinuclear sorting and insulin-regulated recycling of SLC2A4/GLUT4 in adipocytes (By similarity).
Biological Process
Actin cytoskeleton organization Source: GO_Central
Endocytosis Source: UniProtKB-KW
Protein transport Source: UniProtKB-KW
Cellular Location
Endosome; Cytoplasm; Membrane. Mostly found in cytosol and plasma membrane.
Involvement in disease
Prostate cancer, hereditary, 12 (HPC12):
A condition associated with familial predisposition to cancer of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma.
PTM
Prenylated (Probable). Farnelysation (predominant) and geranylgeranylation has been observed in vitro.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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