EHBP1

This gene encodes an Eps15 homology domain binding protein. The encoded protein may play a role in endocytic trafficking. A single nucleotide polymorphism in this gene is associated with an aggressive form of prostate cancer. Alternate splicing results in multiple transcript variants.

Full Name

EH Domain Binding Protein 1

Research Area

May play a role in actin reorganization. Links clathrin-mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking (PubMed:14676205, PubMed:27552051).

Required for perinuclear sorting and insulin-regulated recycling of SLC2A4/GLUT4 in adipocytes (By similarity).

Biological Process

Actin cytoskeleton organization Source: GO_Central
Endocytosis Source: UniProtKB-KW
Protein transport Source: UniProtKB-KW

Cellular Location

Endosome; Cytoplasm; Membrane. Mostly found in cytosol and plasma membrane.

Involvement in disease

Prostate cancer, hereditary, 12 (HPC12):
A condition associated with familial predisposition to cancer of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma.

PTM

Prenylated (Probable). Farnelysation (predominant) and geranylgeranylation has been observed in vitro.