Rabbit Anti-EI24 Recombinant Antibody (CP1968) (V2LY-0425-LY1620)

Name: Rabbit Anti-EI24 Recombinant Antibody (CP1968)
SKU: V2LY-0425-LY1620
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

CP1968

Application

WB, IP

Immunogen

Synthetic peptide corresponding to residues surrounding Ala31 of human EI24 protein.

Host Species

Rabbit

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:1,000
IP	1:200

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

BSA & Glycerol & HEPES

Preservative

Sodium Azide

Concentration

Batch dependent

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

EI24, Autophagy Associated Transmembrane Protein

Entrez Gene ID

Human	9538
Mouse	13663
Rat	300514

UniProt ID

Human	O14681
Mouse	Q61070
Rat	Q4KM77

Research Area

Acts as a negative growth regulator via p53-mediated apoptosis pathway. Regulates formation of degradative autolysosomes during autophagy (By similarity).

Biological Process

Apoptotic process Source: ProtInc
Macroautophagy Source: GO_Central
Negative regulation of cell growth Source: MGI

Cellular Location

Endoplasmic reticulum membrane; Nucleus membrane; Cytoplasm

Involvement in disease

EI24 is on a chromosomal region frequently deleted in solid tumors, and it is thought to play a role in breast and cervical cancer. Particularly, expression analysis of EI24 in cancerous tissues shows that EI24 loss is associated with tumor invasiveness.

Zhang, X., Mao, Y., Peng, W., Liu, H., Liang, L., Wang, D., ... & Zhang, X. (2021). Autophagy-related protein EI24 delays the development of pulmonary fibrosis by promoting autophagy. Life Sciences, 264, 118664.

Zhou, W., Yang, W., Yang, J., Zhu, H., Duan, L., Wang, X., ... & Hong, L. (2021). miR‑483 promotes the development of colorectal cancer by inhibiting the expression level of EI24. Molecular Medicine Reports, 24(2), 1-10.

Yuan, L., Liu, Q., Wang, Z., Hou, J., & Xu, P. (2020). EI24 tethers endoplasmic reticulum and mitochondria to regulate autophagy flux. Cellular and Molecular Life Sciences, 77(8), 1591-1606.

Zang, Y., Zhu, L., Li, T., Wang, Q., Li, J., Qian, Y., ... & Wang, L. (2018). EI24 Suppresses tumorigenesis in pancreatic cancer via regulating c-Myc. Gastroenterology research and practice, 2018.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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