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Mouse Anti-EIF3H Recombinant Antibody (CBFYE-0182) (CBMAB-E0425-FY)

This product is mouse antibody that recognizes EIF3H. The antibody CBFYE-0182 can be used for immunoassay techniques such as: ELISA, WB.
See all EIF3H antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYE-0182
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Eukaryotic Translation Initiation Factor 3 Subunit H
Introduction
EIF3H (Eukaryotic Translation Initiation Factor 3 Subunit H) is a Protein Coding gene. Diseases associated with EIF3H include Trichorhinophalangeal Syndrome, Type I and Trichorhinophalangeal Syndrome, Type Ii. Among its related pathways are Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include translation initiation factor activity.
Entrez Gene ID
8667
UniProt ID
O15372
Alternative Names
Eukaryotic Translation Initiation Factor 3 Subunit H; Eukaryotic Translation Initiation Factor 3, Subunit 3 Gamma, 40kDa; Eukaryotic Translation Initiation Factor 3 Subunit 3; EIF3 P40 Subunit; EIF-3-Gamma; EIF3S3; Eukaryotic Translation Initiation Factor 3, Subunit 3 (Gamma, 40kD)
Research Area
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815).

The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632).

The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).
Biological Process
Formation of cytoplasmic translation initiation complex Source: UniProtKB-UniRule
Negative regulation of proteasomal ubiquitin-dependent protein catabolic process Source: FlyBase
Regulation of translational initiation Source: UniProtKB
Translational initiation Source: UniProtKB
Cellular Location
Cytoplasm

Zheng, R., Zhang, K., Tan, S., Gao, F., Zhang, Y., Xu, W., ... & Wang, M. (2022). Exosomal circLPAR1 functions in colorectal cancer diagnosis and tumorigenesis through suppressing BRD4 via METTL3–eIF3h interaction. Molecular cancer, 21(1), 1-14.

Zhu, Y. D., Ba, H., Chen, J., Zhang, M., & Li, P. (2021). Celastrus orbiculatus Extract Reduces Stemness of Gastric Cancer Stem Cells by Targeting PDCD4 and EIF3H. Integrative Cancer Therapies, 20, 15347354211058168.

Zheng, W., Li, Y., Su, Z., Zhang, J., Shi, F., & Liang, W. (2021). EIF3H knockdown inhibits malignant melanoma through regulating cell proliferation, apoptosis and cell cycle. Experimental Cell Research, 402(1), 112488.

Guo, X., Zhu, R., Luo, A., Zhou, H., Ding, F., Yang, H., & Liu, Z. (2020). EIF3H promotes aggressiveness of esophageal squamous cell carcinoma by modulating Snail stability. Journal of Experimental & Clinical Cancer Research, 39(1), 1-15.

Zhou, Z., Zhou, H., Ponzoni, L., Luo, A., Zhu, R., He, M., ... & Wan, Y. (2020). EIF3H Orchestrates Hippo Pathway–Mediated Oncogenesis via Catalytic Control of YAP StabilityEIF3H Regulates Hippo–YAP Pathway in Tumor Metastasis. Cancer research, 80(12), 2550-2563.

Hu, Y., Wei, X., Lv, Y., Xie, X., Yang, L., He, J., ... & Liu, Z. (2020). EIF3H interacts with PDCD4 enhancing lung adenocarcinoma cell metastasis. American journal of cancer research, 10(1), 179.

Yu, G., Liao, J., Wu, J., Ding, J., & Zhang, L. (2018). The proliferation of colorectal cancer cells is suppressed by silencing of EIF3H. Bioscience, biotechnology, and biochemistry, 82(10), 1694-1701.

Choe, J., Lin, S., Zhang, W., Liu, Q., Wang, L., Ramirez-Moya, J., ... & Gregory, R. I. (2018). mRNA circularization by METTL3–eIF3h enhances translation and promotes oncogenesis. Nature, 561(7724), 556-560.

Wang, X., Wang, H., Zhao, S., Sun, P., Wen, D., Liu, T., ... & Ma, Z. (2018). Eukaryotic translation initiation factor EIF3H potentiates gastric carcinoma cell proliferation. Tissue and Cell, 53, 23-29.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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