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EIF3H

EIF3H (Eukaryotic Translation Initiation Factor 3 Subunit H) is a Protein Coding gene. Diseases associated with EIF3H include Trichorhinophalangeal Syndrome, Type I and Trichorhinophalangeal Syndrome, Type Ii. Among its related pathways are Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include translation initiation factor activity.
Full Name
Eukaryotic Translation Initiation Factor 3 Subunit H
Research Area
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815).

The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632).

The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).
Biological Process
Formation of cytoplasmic translation initiation complex Source: UniProtKB-UniRule
Negative regulation of proteasomal ubiquitin-dependent protein catabolic process Source: FlyBase
Regulation of translational initiation Source: UniProtKB
Translational initiation Source: UniProtKB
Cellular Location
Cytoplasm
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Anti-EIF3H antibodies

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Mouse Anti-EIF3H Recombinant Antibody (3C6) (V2LY-0425-LY1698)

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Target: EIF3H
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse
Clone: 3C6
Application*: E
Datasheet SDS

Mouse Anti-EIF3H Recombinant Antibody (3B12) (V2LY-0425-LY1697)

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Target: EIF3H
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse
Clone: 3B12
Application*: WB, E
Datasheet SDS

Mouse Anti-EIF3H Recombinant Antibody (CBFYE-0684) (V2LY-0425-LY1696)

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Target: EIF3H
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBFYE-0684
Application*: WB, IH
Datasheet SDS

Mouse Anti-EIF3H Recombinant Antibody (CBFYE-0182) (V2LY-0425-LY1695)

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Target: EIF3H
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBFYE-0182
Application*: E, IF, IP, WB
Datasheet SDS

Mouse Anti-EIF3H Recombinant Antibody (3C6) (CBMAB-A2534-LY)

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Target: EIF3H
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3C6
Application*: SE, E
Datasheet SDS

Mouse Anti-EIF3H Recombinant Antibody (3B12) (CBMAB-A2533-LY)

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Target: EIF3H
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3B12
Application*: WB, E
Datasheet SDS

Rabbit Anti-EIF3H Recombinant Antibody (CBFYE-0684) (CBMAB-E1105-FY)

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Target: EIF3H
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: CBFYE-0684
Application*: WB, IP, P, IF
Datasheet SDS

Mouse Anti-EIF3H Recombinant Antibody (CBFYE-0182) (CBMAB-E0425-FY)

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Target: EIF3H
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYE-0182
Application*: E, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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