Rabbit Anti-EIF4E3 Recombinant Antibody (EG1071) (CBMAB-EN1264-LY)

The product is antibody recognizes EIF4E3. The antibody EG1071 immunoassay techniques such as: WB: 1:500~1:1000 ELISA: 1:10000.
See all EIF4E3 antibodies

Datasheet

Summary

Host Animal

Rabbit

Specificity

Human, Mouse, Rat

Clone

EG1071

Antibody Isotype

IgG

Application

WB: 1:500~1:1000 ELISA: 1:10000

Basic Information

Immunogen

The antibody was produced against synthesized peptide derived from internal of human EIF4E3.

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

Eukaryotic Translation Initiation Factor 4E Family Member 3

Introduction

EIF4E3 belongs to the EIF4E family of translational initiation factors that interact with the 5-prime cap structure of mRNA and recruit mRNA to the ribosome (Joshi et al., 2004 [PubMed 15153109]).[supplied by OMIM, Mar 2008]

Entrez Gene ID

Human	317649
Mouse	66892
Rat	297481

UniProt ID

Human	Q8N5X7
Mouse	Q9DBB5
Rat	B5DF58

Alternative Names

Eukaryotic Translation Initiation Factor 4E Family Member 3; EIF-4E3; EIF4E-3; Eukaryotic Translation Initiation Factor 4E Member 3; Eukaryotic Translation Initiation Factor 4E Type 3; EIF-4E Type 3; EIF4E Type 3;

Research Area

Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis. May act as an inhibitor of EIF4E1 activity (By similarity).

Cellular Location

Cytosol; Eukaryotic translation initiation factor 4F complex; mRNA cap binding complex

References

Weiss, B., Allen, G. E., Kloehn, J., Abid, K., Jaquier-Gubler, P., & Curran, J. A. (2021). eIF4E3 forms an active eIF4F complex during stresses (eIF4FS) targeting mTOR and re-programs the translatome. Nucleic acids research, 49(9), 5159-5176.

Weiss, B. (2019). Crossroads at translation initiation: the long and the short of a short and a long 5'transcript leader and the eukaryotic initiation factor eIF4E3 (Doctoral dissertation, University of Geneva).

Mrvová, S., Frydrýšková, K., Pospíšek, M., Vopálenský, V., & Mašek, T. (2018). Major splice variants and multiple polyadenylation site utilization in mRNAs encoding human translation initiation factors eIF4E1 and eIF4E3 regulate the translational regulators?. Molecular Genetics and Genomics, 293(1), 167-186.

Ruibin, W., Zheng, X., Chen, J., Zhang, X., Yang, X., & Lin, Y. (2018). Micro RNA-1298 opposes the effects of chronic oxidative stress on human trabecular meshwork cells via targeting on EIF4E3. Biomedicine & Pharmacotherapy, 100, 349-357.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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