Mouse Anti-EIF4E3 Recombinant Antibody (EG1071) (V2LY-0425-LY1742)

Name: Mouse Anti-EIF4E3 Recombinant Antibody (EG1071)
SKU: V2LY-0425-LY1742
Rating: 5 (1 reviews)

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Summary

Host Animal

Mouse

Specificity

Human, Mouse, Rat

Clone

EG1071

Antibody Isotype

IgG1

Application

Basic Information

Immunogen

Full length recombinant EIF4E2.

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:2,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

BSA & Glycerol & PBS

Preservative

Sodium Azide

Concentration

1 mg/ml

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

Eukaryotic Translation Initiation Factor 4E Family Member 3

Entrez Gene ID

Human	317649
Mouse	66892
Rat	297481

UniProt ID

Human	Q8N5X7
Mouse	Q9DBB5
Rat	B5DF58

Research Area

Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis. May act as an inhibitor of EIF4E1 activity (By similarity).

Cellular Location

Cytosol; Eukaryotic translation initiation factor 4F complex; mRNA cap binding complex

More Infomation

References

Weiss, B., Allen, G. E., Kloehn, J., Abid, K., Jaquier-Gubler, P., & Curran, J. A. (2021). eIF4E3 forms an active eIF4F complex during stresses (eIF4FS) targeting mTOR and re-programs the translatome. Nucleic acids research, 49(9), 5159-5176.

Weiss, B. (2019). Crossroads at translation initiation: the long and the short of a short and a long 5'transcript leader and the eukaryotic initiation factor eIF4E3 (Doctoral dissertation, University of Geneva).

Mrvová, S., Frydrýšková, K., Pospíšek, M., Vopálenský, V., & Mašek, T. (2018). Major splice variants and multiple polyadenylation site utilization in mRNAs encoding human translation initiation factors eIF4E1 and eIF4E3 regulate the translational regulators?. Molecular Genetics and Genomics, 293(1), 167-186.

Ruibin, W., Zheng, X., Chen, J., Zhang, X., Yang, X., & Lin, Y. (2018). Micro RNA-1298 opposes the effects of chronic oxidative stress on human trabecular meshwork cells via targeting on EIF4E3. Biomedicine & Pharmacotherapy, 100, 349-357.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Alternative Versions

Rabbit Anti-EIF4E3 Recombinant Antibody (EG1071)

Related Products

Rabbit Anti-EIF4E3 Recombinant Antibody (EG1071)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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